| Literature DB >> 25814189 |
Nicoletta Fotino1, Carmen Fotino2, Antonello Pileggi3.
Abstract
We are living exciting times in the field of beta cell replacement therapies for the treatment of diabetes. While steady progress has been recorded thus far in clinical islet transplantation, novel approaches are needed to make cell-based therapies more reproducible and leading to long-lasting success. The multiple facets of diabetes impose the need for a transdisciplinary approach to attain this goal, by targeting immunity, promoting engraftment and sustained functional potency. We discuss herein the emerging technologies applied to this rapidly evolving field.Entities:
Keywords: Beta cells; Biomaterials; Cellular therapies; Diabetes; Implantable devices; Insulin; Islet transplantation; Islets of Langerhans; Stem cells; Tissue engineering
Mesh:
Year: 2015 PMID: 25814189 PMCID: PMC4469528 DOI: 10.1016/j.phrs.2015.02.010
Source DB: PubMed Journal: Pharmacol Res ISSN: 1043-6618 Impact factor: 7.658