| Literature DB >> 7968077 |
C G Groth1, O Korsgren, A Tibell, J Tollemar, E Möller, J Bolinder, J Ostman, F P Reinholt, C Hellerström, A Andersson.
Abstract
Transplantation of fetal porcine islet-like cell clusters (ICC) reverses diabetes in experimental animals. We have now transplanted porcine ICC to ten insulin-dependent diabetic kidney-transplant patients. All patients received standard immunosuppression and, at ICC transplantation, antithymocyte globulin or 15-deoxyspergualin. ICC were injected intraportally or placed under the kidney capsule of the renal graft. Four patients excreted small amounts of porcine C-peptide in urine for 200-400 days. In one renal-graft biopsy specimen, morphologically intact epithelial cells stained positively for insulin and glucagon in the subcapsular space. We conclude that porcine pancreatic endocrine tissue can survive in the human body.Entities:
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Year: 1994 PMID： 7968077 DOI： 10.1016/s0140-6736(94)90570-3
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321