| Literature DB >> 25812075 |
Catherine M Clavel1, Emilia Păunescu1, Patrycja Nowak-Sliwinska1, Arjan W Griffioen2, Rosario Scopelliti1, Paul J Dyson1.
Abstract
Following the identification of [Ru(η(6)-p-cymene)Cl2(1H,1H,2H,2H-perfluorodecyl-3-(pyridin-3-yl)propanoate)], a ruthenium(II)-arene complex with a perfluoroalkyl-modified ligand that displays remarkable in vitro cancer cell selectivity, a series of structurally related compounds were designed. In the new derivatives, the p-cymene ring and/or the chloride ligands are substituted by other ligands to modulate the steric bulk or aquation kinetics. The new compounds were evaluated in both in vitro (cytotoxicity and migration assays) and in vivo (chicken chorioallantoic membrane) models and were found to exhibit potent antivascular effects.Entities:
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Year: 2015 PMID： 25812075 DOI： 10.1021/jm501655t
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446