| Literature DB >> 25811955 |
Diego de Souza1, Douglas O C Mariano1, Fernanda Nedel2, Eduarda Schultze2, Vinícius F Campos2, Fabiana Seixas2, Rafael S da Silva1, Taiana S Munchen1, Vinicius Ilha1, Luciano Dornelles1, Antonio L Braga3, João B T Rocha1, Tiago Collares2, Oscar E D Rodrigues1.
Abstract
In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of TBARS in brain membranes and thiol peroxidase-like activity) as well as antitumoral agents in bladder carcinoma 5637. A prominent response was obtained for the selected chalcogenonucleosides, showing effective antioxidant and antitumoral activities.Entities:
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Year: 2015 PMID： 25811955 DOI： 10.1021/jm5015296
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446