Melissa A Munn-Chernoff1, Pamela K Keel2, Kelly L Klump3, Julia D Grant1, Kathleen K Bucholz1, Pamela A F Madden1, Andrew C Heath1, Alexis E Duncan1,4. 1. Department of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St. Louis, Missouri. 2. Department of Psychology, Florida State University, Tallahassee, Florida. 3. Department of Psychology, Michigan State University, East Lansing, Michigan. 4. George Warren Brown School of Social Work, Washington University, St. Louis, Missouri.
Abstract
OBJECTIVE: Purging disorder (PD) was recently included as an otherwise specified feeding or eating disorder (OSFED) in the DSM-5; however, limited information is available on its prevalence, and its etiology is unknown. METHOD: Data from 1,790 monozygotic and 1,440 dizygotic European American female twins (age range = 18-29 years) from the Missouri Adolescent Female Twin Study were used to investigate prevalence and familial influences for PD. A structured clinical interview assessed lifetime DSM-IV criteria for eating disorders and PD. After adjustment for age, twin correlations and biometrical twin models were used to estimate familial (i.e., genetic plus shared environmental) influences on PD. RESULTS: One hundred and twenty one (3.77%; 95% CI: 3.14, 4.49) women met criteria for lifetime PD. Twin correlations suggested that genetic, shared environmental, and nonshared environmental factors influenced liability to PD. Nonshared environmental factors accounted for 56% [35%, 79%] of the variance in PD. Although familial effects accounted for a significant proportion of variance (44% [21%, 65%]), it was not possible to disentangle the independent contributions of additive genetic effects (20% [0%, 65%]) and shared environmental effects (24% [0%, 57%]). DISCUSSION: PD is a prevalent form of eating pathology. Familial factors are relevant to the development of PD but do not demonstrate the magnitude of heritable factors found for other eating disorders.
OBJECTIVE: Purging disorder (PD) was recently included as an otherwise specified feeding or eating disorder (OSFED) in the DSM-5; however, limited information is available on its prevalence, and its etiology is unknown. METHOD: Data from 1,790 monozygotic and 1,440 dizygotic European American female twins (age range = 18-29 years) from the Missouri Adolescent Female Twin Study were used to investigate prevalence and familial influences for PD. A structured clinical interview assessed lifetime DSM-IV criteria for eating disorders and PD. After adjustment for age, twin correlations and biometrical twin models were used to estimate familial (i.e., genetic plus shared environmental) influences on PD. RESULTS: One hundred and twenty one (3.77%; 95% CI: 3.14, 4.49) women met criteria for lifetime PD. Twin correlations suggested that genetic, shared environmental, and nonshared environmental factors influenced liability to PD. Nonshared environmental factors accounted for 56% [35%, 79%] of the variance in PD. Although familial effects accounted for a significant proportion of variance (44% [21%, 65%]), it was not possible to disentangle the independent contributions of additive genetic effects (20% [0%, 65%]) and shared environmental effects (24% [0%, 57%]). DISCUSSION: PD is a prevalent form of eating pathology. Familial factors are relevant to the development of PD but do not demonstrate the magnitude of heritable factors found for other eating disorders.
Authors: L N Robins; J Wing; H U Wittchen; J E Helzer; T F Babor; J Burke; A Farmer; A Jablenski; R Pickens; D A Regier Journal: Arch Gen Psychiatry Date: 1988-12
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Authors: Melissa A Munn-Chernoff; Alexis E Duncan; Julia D Grant; Tracey D Wade; Arpana Agrawal; Kathleen K Bucholz; Pamela A F Madden; Nicholas G Martin; Andrew C Heath Journal: J Stud Alcohol Drugs Date: 2013-09 Impact factor: 2.582
Authors: Melissa A Munn-Chernoff; Lauren R Few; Camden E Matherne; Jessica H Baker; Vera Yu Men; Vivia V McCutcheon; Arpana Agrawal; Kathleen K Bucholz; Pamela A F Madden; Andrew C Heath; Alexis E Duncan Journal: Drug Alcohol Depend Date: 2020-04-25 Impact factor: 4.492
Authors: Claire M Peterson; Jessica H Baker; Laura M Thornton; Sara E Trace; Suzanne E Mazzeo; Michael C Neale; Melissa A Munn-Chernoff; Paul Lichtenstein; Nancy L Pedersen; Cynthia M Bulik Journal: Int J Eat Disord Date: 2015-12-29 Impact factor: 4.861
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