Nasim Taghavi1, Sara Bagheri2, Alireza Akbarzadeh3. 1. Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Oral & Maxillofacial Pathology, Guilan University of Medical Sciences, Rasht, Iran. 3. Department of Basic Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
BACKGROUND: Natural killer (NK) cells are important immune effector cells against tumors especially in the absence or reducing MHC class I antigen. Downregulation of CD16 receptor is accompanied by decreasing NK cell-killing activity. It has also been shown that some of tumor cells can evade from immune system through producing transforming growth factor beta (TGF-β) and affect prognosis. The objective of this study was to evaluate the prognostic significance of CD57(+) and CD16(+) cells and TGF-β expression in samples of oral squamous cell carcinoma (OSCC). METHODS: CD57, CD16, and TGF-β expressions were examined immunohistochemically in 57 cases of OSCC. The relationship between markers' expression and clinicopathologic data using bivariate and multivariate analysis was assessed. RESULTS: Multivariate analysis revealed that CD57 expression [HR 17.34 (95% CI 3.815-78.830); P < 0.001] and mode of invasion [HR 0.362 (95% CI 0.138-0.947); P = 0.038] correlated with survival rate, but no relation between CD57 expression and mode of invasion was seen (P = 0.96). Furthermore, no correlation between CD57, CD16, and TGF-β expression was found. CONCLUSION: These findings suggest that CD57 expression and mode of invasion are independent prognostic factors of survival in OSCC patients.
BACKGROUND: Natural killer (NK) cells are important immune effector cells against tumors especially in the absence or reducing MHC class I antigen. Downregulation of CD16 receptor is accompanied by decreasing NK cell-killing activity. It has also been shown that some of tumor cells can evade from immune system through producing transforming growth factor beta (TGF-β) and affect prognosis. The objective of this study was to evaluate the prognostic significance of CD57(+) and CD16(+) cells and TGF-β expression in samples of oral squamous cell carcinoma (OSCC). METHODS:CD57, CD16, and TGF-β expressions were examined immunohistochemically in 57 cases of OSCC. The relationship between markers' expression and clinicopathologic data using bivariate and multivariate analysis was assessed. RESULTS: Multivariate analysis revealed that CD57 expression [HR 17.34 (95% CI 3.815-78.830); P < 0.001] and mode of invasion [HR 0.362 (95% CI 0.138-0.947); P = 0.038] correlated with survival rate, but no relation between CD57 expression and mode of invasion was seen (P = 0.96). Furthermore, no correlation between CD57, CD16, and TGF-β expression was found. CONCLUSION: These findings suggest that CD57 expression and mode of invasion are independent prognostic factors of survival in OSCC patients.
Authors: Quaovi H Sodji; Dhanya K Nambiar; Vignesh Viswanathan; Rie von Eyben; Deana Colburg; Michael S Binkley; Caiyun G Li; Monica M Olcina; Daniel T Chang; Quynh-Thu Le; Amato J Giaccia Journal: Cancer Res Commun Date: 2022-07-27
Authors: Juan Fang; Xiaoxu Li; Da Ma; Xiangqi Liu; Yichen Chen; Yun Wang; Vivian Wai Yan Lui; Juan Xia; Bin Cheng; Zhi Wang Journal: BMC Cancer Date: 2017-05-26 Impact factor: 4.430