Literature DB >> 25806265

Endothelial Dll4-Notch signaling in tumor microenvironment: is there any hidden therapeutic opportunity?

Amit Kumar1, Sejal Desai1, Badri N Pandey1.   

Abstract

Tumor microenvironmental cross-talk between endothelial and cancer cells plays an essential role in growth, progression and therapeutic outcome of cancer. In response to tumor cell-derived vascular endothelial growth factor (VEGF), the endothelial delta-like ligand 4 (Dll4) regulates angiogenesis and tumor growth via Notch signaling. However, in view of intriguing effects of emerging Dll4-Notch signaling in various tumor types, the missing links need to be elucidated for development of this signaling as a possible therapeutic target for cancer therapy.

Entities:  

Keywords:  Dll4-Notch receptor cross-talk; Tumor microenvironment; angiogenesis; cancer therapy; vascular endothelial growth factor signaling

Year:  2013        PMID： 25806265      PMCID： PMC4367634          DOI： 10.3978/j.issn.2218-6751.2013.09.01

Source DB:  PubMed          Journal:  Transl Lung Cancer Res        ISSN： 2218-6751


  18 in total

Review 1.  Hypoxia--a key regulatory factor in tumour growth.

Authors:  Adrian L Harris
Journal:  Nat Rev Cancer       Date:  2002-01       Impact factor: 60.716

2.  Chronic DLL4 blockade induces vascular neoplasms.

Authors:  Minhong Yan; Christopher A Callahan; Joseph C Beyer; Krishna P Allamneni; Gu Zhang; John Brady Ridgway; Kyle Niessen; Greg D Plowman
Journal:  Nature       Date:  2010-02-11       Impact factor: 49.962

3.  Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

Authors:  Irene Noguera-Troise; Christopher Daly; Nicholas J Papadopoulos; Sandra Coetzee; Pat Boland; Nicholas W Gale; Hsin Chieh Lin; George D Yancopoulos; Gavin Thurston
Journal:  Nature       Date:  2006-12-21       Impact factor: 49.962

4.  Identification and functional analysis of endothelial tip cell-enriched genes.

Authors:  Raquel del Toro; Claudia Prahst; Thomas Mathivet; Geraldine Siegfried; Joshua S Kaminker; Bruno Larrivee; Christiane Breant; Antonio Duarte; Nobuyuki Takakura; Akiyoshi Fukamizu; Josef Penninger; Anne Eichmann
Journal:  Blood       Date:  2010-08-12       Impact factor: 22.113

5.  Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.

Authors:  Teresa Palomero; Maria Luisa Sulis; Maria Cortina; Pedro J Real; Kelly Barnes; Maria Ciofani; Esther Caparros; Jean Buteau; Kristy Brown; Sherrie L Perkins; Govind Bhagat; Archana M Agarwal; Giuseppe Basso; Mireia Castillo; Satoru Nagase; Carlos Cordon-Cardo; Ramon Parsons; Juan Carlos Zúñiga-Pflücker; Maria Dominguez; Adolfo A Ferrando
Journal:  Nat Med       Date:  2007-09-16       Impact factor: 53.440

6.  Autocrine IL-8 and VEGF mediate epithelial-mesenchymal transition and invasiveness via p38/JNK-ATF-2 signalling in A549 lung cancer cells.

Authors:  Sejal Desai; S Laskar; B N Pandey
Journal:  Cell Signal       Date:  2013-05-25       Impact factor: 4.315

Review 7.  Targeting tumor neovasculature in non-small-cell lung cancer.

Authors:  Athanasios G Pallis; Konstantinos N Syrigos
Journal:  Crit Rev Oncol Hematol       Date:  2012-11-15       Impact factor: 6.312

8.  Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway.

Authors:  Irene Graziani; Sandra Eliasz; Melissa A De Marco; Yuanbin Chen; Harvey I Pass; Richard M De May; Peter R Strack; Lucio Miele; Maurizio Bocchetta
Journal:  Cancer Res       Date:  2008-12-01       Impact factor: 12.701

Review 9.  Notch signaling in blood vessels: who is talking to whom about what?

Authors:  Jennifer J Hofmann; M Luisa Iruela-Arispe
Journal:  Circ Res       Date:  2007-06-08       Impact factor: 17.367

10.  A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.

Authors:  Eleni Andriana Trigka; Georgia Levidou; Angelica A Saetta; Ilenia Chatziandreou; Periklis Tomos; Nikolaos Thalassinos; Nikolaos Anastasiou; Eleftherios Spartalis; Nikolaos Kavantzas; Efstratios Patsouris; Penelope Korkolopoulou
Journal:  Oncol Rep       Date:  2013-05-31       Impact factor: 3.906
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  1 in total

Review 1.  Shooting at Moving and Hidden Targets-Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas.

Authors:  Joanna Kałafut; Arkadiusz Czerwonka; Alinda Anameriç; Alicja Przybyszewska-Podstawka; Julia O Misiorek; Adolfo Rivero-Müller; Matthias Nees
Journal:  Cancers (Basel)       Date:  2021-12-10       Impact factor: 6.639
  1 in total

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