| Literature DB >> 20147986 |
Minhong Yan1, Christopher A Callahan, Joseph C Beyer, Krishna P Allamneni, Gu Zhang, John Brady Ridgway, Kyle Niessen, Greg D Plowman.
Abstract
Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.Entities:
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Year: 2010 PMID： 20147986 DOI： 10.1038/nature08751
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962