Meredith Sadinski1, Milica Medved2, Ibrahim Karademir3,4, Shiyang Wang5, Yahui Peng6,7, Yulei Jiang8, Steffen Sammet9, Gregory Karczmar10, Aytekin Oto11. 1. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. sadinski@uchicago.edu. 2. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. mmedved@uchicago.edu. 3. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. drikarademir@hotmail.com. 4. Department of Radiology, Eskisehir Military Hospital, 26020, Eskisehir, Turkey. drikarademir@hotmail.com. 5. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. shiyang219@gmail.com. 6. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. yhpeng@btju.edu.cn. 7. School of Electronic and Information Engineering, Beijing Jiaotong University, No. 3 Shangyuancun, Haidian District, Beijing, 100044, China. yhpeng@btju.edu.cn. 8. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. y-jiang@uchicago.edu. 9. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. ssammet@radiology.bsd.uchicago.edu. 10. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. gskarczm@uchicago.edu. 11. Department of Radiology, University of Chicago, 5841 S. Maryland Avenue, MC 2026, Chicago, IL, 60637, USA. aoto@radiology.bsd.uchicago.edu.
Abstract
PURPOSE: The purpose of the study is to determine short-term reproducibility of apparent diffusion coefficient (ADC) estimated from diffusion-weighted magnetic resonance (DW-MR) imaging of the prostate. METHODS: Fourteen patients with biopsy-proven prostate cancer were studied under an Institutional Review Board-approved protocol. Each patient underwent two, consecutive and identical DW-MR scans on a 3T system. ADC values were calculated from each scan and a deformable registration was performed to align corresponding images. The prostate and cancerous regions of interest (ROIs) were independently analyzed by two radiologists. The prostate volume was analyzed by sextant. Per-voxel absolute and relative percentage variations in ADC were compared between sextants. Per-voxel and per-ROI variations in ADC were calculated for cancerous ROIs. RESULTS: Per-voxel absolute difference in ADC in the prostate ranged from 0 to 1.60 × 10(-3) mm(2)/s (per-voxel relative difference 0% to 200%, mean 10.5%). Variation in ADC was largest in the posterior apex (0% to 200%, mean 11.6%). Difference in ADC variation between sextants was not statistically significant. Cancer ROIs' per-voxel variation in ADC ranged from 0.001 × 10(-3) to 0.841 × 10(-3) mm(2)/s (0% to 67.4%, mean 11.2%) and per-ROI variation ranged from 0 to 0.463 × 10(-3) mm(2)/s (mean 0.122 × 10(-3) mm(2)/s). CONCLUSIONS: Variation in ADC within the human prostate is reasonably small, and is on the order of 10%.
PURPOSE: The purpose of the study is to determine short-term reproducibility of apparent diffusion coefficient (ADC) estimated from diffusion-weighted magnetic resonance (DW-MR) imaging of the prostate. METHODS: Fourteen patients with biopsy-proven prostate cancer were studied under an Institutional Review Board-approved protocol. Each patient underwent two, consecutive and identical DW-MR scans on a 3T system. ADC values were calculated from each scan and a deformable registration was performed to align corresponding images. The prostate and cancerous regions of interest (ROIs) were independently analyzed by two radiologists. The prostate volume was analyzed by sextant. Per-voxel absolute and relative percentage variations in ADC were compared between sextants. Per-voxel and per-ROI variations in ADC were calculated for cancerous ROIs. RESULTS: Per-voxel absolute difference in ADC in the prostate ranged from 0 to 1.60 × 10(-3) mm(2)/s (per-voxel relative difference 0% to 200%, mean 10.5%). Variation in ADC was largest in the posterior apex (0% to 200%, mean 11.6%). Difference in ADC variation between sextants was not statistically significant. Cancer ROIs' per-voxel variation in ADC ranged from 0.001 × 10(-3) to 0.841 × 10(-3) mm(2)/s (0% to 67.4%, mean 11.2%) and per-ROI variation ranged from 0 to 0.463 × 10(-3) mm(2)/s (mean 0.122 × 10(-3) mm(2)/s). CONCLUSIONS: Variation in ADC within the human prostate is reasonably small, and is on the order of 10%.
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