J-P Kühn1, M C Spoerl, C Mahlke, K Hegenscheid. 1. Abteilung Experimentelle Radiologie, Institut für Diagnostische Radiologie und Neuroradiologie, Universitätsmedizin Greifswald, Sauerbruchstr. 1, 17489, Greifswald, Deutschland, kuehn@uni-greifswald.de.
Abstract
CLINICAL/METHODICAL ISSUE: Fatty liver disease plays an important role in the development of type 2 diabetes. Accurate techniques for detection and quantification of liver fat are essential for clinical diagnostics. STANDARD RADIOLOGICAL METHODS: Chemical shift-encoded magnetic resonance imaging (MRI) is a simple approach to quantify liver fat content. METHODICAL INNOVATIONS: Liver fat quantification using chemical shift-encoded MRI is influenced by several bias factors, such as T2* decay, T1 recovery and the multispectral complexity of fat. PERFORMANCE: The confounder corrected proton density fat fraction is a simple approach to quantify liver fat with comparable results independent of the software and hardware used. ACHIEVEMENTS: The proton density fat fraction is an accurate biomarker for assessment of liver fat. PRACTICAL RECOMMENDATIONS: An accurate and reproducible quantification of liver fat using chemical shift-encoded MRI requires a calculation of the proton density fat fraction.
CLINICAL/METHODICAL ISSUE: Fatty liver disease plays an important role in the development of type 2 diabetes. Accurate techniques for detection and quantification of liver fat are essential for clinical diagnostics. STANDARD RADIOLOGICAL METHODS: Chemical shift-encoded magnetic resonance imaging (MRI) is a simple approach to quantify liver fat content. METHODICAL INNOVATIONS: Liver fat quantification using chemical shift-encoded MRI is influenced by several bias factors, such as T2* decay, T1 recovery and the multispectral complexity of fat. PERFORMANCE: The confounder corrected proton density fat fraction is a simple approach to quantify liver fat with comparable results independent of the software and hardware used. ACHIEVEMENTS: The proton density fat fraction is an accurate biomarker for assessment of liver fat. PRACTICAL RECOMMENDATIONS: An accurate and reproducible quantification of liver fat using chemical shift-encoded MRI requires a calculation of the proton density fat fraction.
Authors: Jens-Peter Kühn; Diego Hernando; Birger Mensel; Paul C Krüger; Till Ittermann; Julia Mayerle; Norbert Hosten; Scott B Reeder Journal: J Magn Reson Imaging Date: 2013-10-10 Impact factor: 4.813
Authors: Geraldine H Kang; Irene Cruite; Masoud Shiehmorteza; Tanya Wolfson; Anthony C Gamst; Gavin Hamilton; Mark Bydder; Michael S Middleton; Claude B Sirlin Journal: J Magn Reson Imaging Date: 2011-07-18 Impact factor: 4.813
Authors: D K George; S Goldwurm; G A MacDonald; L L Cowley; N I Walker; P J Ward; E C Jazwinska; L W Powell Journal: Gastroenterology Date: 1998-02 Impact factor: 22.682
Authors: T Tamayo; J Rosenbauer; S H Wild; A M W Spijkerman; C Baan; N G Forouhi; C Herder; W Rathmann Journal: Diabetes Res Clin Pract Date: 2013-12-01 Impact factor: 5.602