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Literature DB >> 25801473

The changing landscape in translocator protein (TSPO) function.

Abstract

Translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), is an outer mitochondrial membrane protein. TSPO has been shown to cooperate with steroidogenic acute regulatory protein (StAR) and function in the transport of cholesterol into mitochondria. TSPO has also been considered as a structural component of the mitochondrial permeability transition pore (MPTP). However, recent advances have changed these views of TSPO's functions and have prompted a re-evaluation of established concepts. This review summarizes the history of TSPO, key elements of the debate, and functional experiments that have changed our understanding. Moving forward, we examine how this fundamental change impacts our understanding of TSPO and affects the future of TSPO as a therapeutic and diagnostic target.

Entities: CellLine Chemical Disease Gene Species

Keywords: benzodiazepine; cholesterol; mitochondria; permeability transition; steroid hormone; therapy

Mesh：

Substances：

Year: 2015 PMID： 25801473 PMCID： PMC7171652 DOI： 10.1016/j.tem.2015.02.007

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

80 in total

1. Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.

Authors: Kanako Morohaku; Susanne H Pelton; Daniel J Daugherty; W Ronald Butler; Wenbin Deng; Vimal Selvaraj
Journal: Endocrinology Date: 2013-12-20 Impact factor: 4.736

2. Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue.

Authors: B Chelli; A Falleni; F Salvetti; V Gremigni; A Lucacchini; C Martini
Journal: Biochem Pharmacol Date: 2001-03-15 Impact factor: 5.858

Review 3. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders.

Authors: Rainer Rupprecht; Vassilios Papadopoulos; Gerhard Rammes; Thomas C Baghai; Jinjiang Fan; Nagaraju Akula; Ghislaine Groyer; David Adams; Michael Schumacher
Journal: Nat Rev Drug Discov Date: 2010-12 Impact factor: 84.694

4. PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism.

Authors: Roland B Walter; Jason L Pirga; Michelle R Cronk; Sasha Mayer; Frederick R Appelbaum; Deborah E Banker
Journal: Blood Date: 2005-07-28 Impact factor: 22.113

5. TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance.

Authors: Barbara Costa; Eleonora Da Pozzo; Chiara Giacomelli; Sabrina Taliani; Sara Bendinelli; Elisabetta Barresi; Federico Da Settimo; Claudia Martini
Journal: Apoptosis Date: 2015-03 Impact factor: 4.677

6. Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.

Authors: Janice M W Taylor; Anne-Marie Allen; Annette Graham
Journal: Clin Sci (Lond) Date: 2014-11 Impact factor: 6.124

7. On the role of the translocator protein (18-kDa) TSPO in steroid hormone biosynthesis.

Authors: Vassilios Papadopoulos
Journal: Endocrinology Date: 2014-01 Impact factor: 4.736

8. The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.

Authors: Linhao Li; Tao Chen; Joseph D Stanton; Tatsuya Sueyoshi; Masahiko Negishi; Hongbing Wang
Journal: Mol Pharmacol Date: 2008-05-20 Impact factor: 4.436

Review 9. Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response.

Authors: Leo Veenman; Vassilios Papadopoulos; Moshe Gavish
Journal: Curr Pharm Des Date: 2007 Impact factor: 3.116

10. Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO)).

Authors: Justina Šileikytė; Elizabeth Blachly-Dyson; Randall Sewell; Andrea Carpi; Roberta Menabò; Fabio Di Lisa; Fernanda Ricchelli; Paolo Bernardi; Michael Forte
Journal: J Biol Chem Date: 2014-04-01 Impact factor: 5.157

41 in total

Review 1. Frontiers in positron emission tomography imaging of the vulnerable atherosclerotic plaque.

Authors: Mark G MacAskill; David E Newby; Adriana A S Tavares
Journal: Cardiovasc Res Date: 2019-12-01 Impact factor: 10.787

Review 2. Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry.

Authors: T Notter; J M Coughlin; A Sawa; U Meyer
Journal: Mol Psychiatry Date: 2017-12-05 Impact factor: 15.992

Review 3. A brief history of the search for the protein(s) involved in the acute regulation of steroidogenesis.

Authors: Douglas M Stocco; Amy H Zhao; Lan N Tu; Kanako Morohaku; Vimal Selvaraj
Journal: Mol Cell Endocrinol Date: 2016-07-30 Impact factor: 4.102

4. Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis.

Authors: Amy H Zhao; Lan N Tu; Chinatsu Mukai; Madhu P Sirivelu; Viju V Pillai; Kanako Morohaku; Roy Cohen; Vimal Selvaraj
Journal: J Biol Chem Date: 2015-12-01 Impact factor: 5.157

5. Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with ¹²⁵I-Iodo-DPA-713 SPECT/CT.

Authors: Catherine A Foss; Liansheng Liu; Ronnie C Mease; Haofan Wang; Pankaj Pasricha; Martin G Pomper
Journal: J Nucl Med Date: 2017-05-18 Impact factor: 10.057

Review 6. Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal.

Authors: Vimal Selvaraj; Douglas M Stocco; Lan N Tu
Journal: Mol Endocrinol Date: 2015-03-02

Review 7. Neurosteroid biosynthesis down-regulation and changes in GABA_A receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment.

Authors: Andrea Locci; Graziano Pinna
Journal: Br J Pharmacol Date: 2017-06-14 Impact factor: 8.739

The changing landscape in translocator protein (TSPO) function.

1. Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.

2. Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue.

Review 3. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders.

4. PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism.

5. TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance.

6. Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.

7. On the role of the translocator protein (18-kDa) TSPO in steroid hormone biosynthesis.

8. The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.

Review 9. Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response.

10. Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO)).

Review 1. Frontiers in positron emission tomography imaging of the vulnerable atherosclerotic plaque.

Review 2. Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry.

Review 3. A brief history of the search for the protein(s) involved in the acute regulation of steroidogenesis.

4. Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis.

5. Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with ¹²⁵I-Iodo-DPA-713 SPECT/CT.

Review 6. Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal.

Review 7. Neurosteroid biosynthesis down-regulation and changes in GABA_A receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment.

8. Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells.

Review 9. Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors.

10. Lack of adrenal TSPO/PBR expression in hamsters reinforces correlation to triglyceride metabolism.

Review 3. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders.

Review 9. Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response.

Review 1. Frontiers in positron emission tomography imaging of the vulnerable atherosclerotic plaque.

Review 2. Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry.

Review 3. A brief history of the search for the protein(s) involved in the acute regulation of steroidogenesis.

Review 6. Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal.

Review 7. Neurosteroid biosynthesis down-regulation and changes in GABAA receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment.

Review 9. Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors.

Review 7. Neurosteroid biosynthesis down-regulation and changes in GABA_A receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment.