Literature DB >> 2580051

Comparison of RNA from healthy and scrapie-infected hamster brain.

T L German, B C McMillan, B E Castle, C Dees, W F Wade, R F Marsh.   

Abstract

Density gradient fractions prepared from healthy or scrapie-infected hamster brain tissue enriched in plasma membrane vesicles were treated with nucleases prior to phenol extraction and ethanol precipitation. The recovered nucleic acids were 3' end-labelled and run on one-dimensional polyacrylamide gels. Autoradiography revealed the presence of low molecular weight RNAs (4S) in both healthy and scrapie samples. Two-dimensional fingerprint analysis indicated that the RNAs isolated from scrapie-infected hamsters contained oligonucleotides that were not present in RNAs isolated from healthy hamsters.

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Year:  1985        PMID： 2580051     DOI： 10.1099/0022-1317-66-4-839

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  5 in total

1.  A 54-kDa normal cellular protein may be the precursor of the scrapie agent protease-resistant protein.

Authors:  P E Bendheim; D C Bolton
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

2.  Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains.

Authors:  R J Kascsak; R Rubenstein; P A Merz; R I Carp; N K Robakis; H M Wisniewski; H Diringer
Journal:  J Virol       Date:  1986-09       Impact factor: 5.103

3.  Synthetic scrapie infectivity: interaction between recombinant PrP and scrapie brain-derived RNA.

Authors:  Steve Simoneau; Achim Thomzig; Marie-Madeleine Ruchoux; Nicolas Vignier; Martin L Daus; Anna Poleggi; Pierre Lebon; Sophie Freire; Valerie Durand; Silvia Graziano; Roberta Galeno; Franco Cardone; Emmanuel Comoy; Maurizio Pocchiari; Michael Beekes; Jean-Philippe Deslys; Jean-Guy Fournier
Journal:  Virulence       Date:  2015-01-13       Impact factor: 5.882

4.  Conservation of infectivity in purified fibrillary extracts of scrapie-infected hamster brain after sequential enzymatic digestion or polyacrylamide gel electrophoresis.

Authors:  P Brown; P P Liberski; A Wolff; D C Gajdusek
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

Review 5.  The molecular mechanisms of scrapie encephalopathy and relevance to human neurodegenerative disease.

Authors:  W J Lukiw; H J Cho; J C Kaufmann; D R Crapper McLachlan
Journal:  Can J Vet Res       Date:  1990-01       Impact factor: 1.310
  5 in total

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