Irem Fatma Uludag1, Tarik Duksal2, Bedile Irem Tiftikcioglu2, Yasar Zorlu2, Feriha Ozkaya3, Guldal Kirkali3. 1. Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey. Electronic address: fatmairem@yahoo.com. 2. Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey. 3. Dokuz Eylul University Faculty of Medicine, Department of Medical Biochemistry, Turkey.
Abstract
PURPOSE: There is now extensive evidence to support the involvement of inflammation in the course of epileptic seizures. Seizure-induced changes in serum IL-1β, IL-6 and IL-1Ra levels are reported in several studies. Serum cytokine levels may also be disturbed in inter-ictal period due to seizure activity. METHODS: Twenty-one patients (12 women; mean age 35±12.3) with temporal lobe epilepsy (TLE), 17 patients (8 women; mean age 31.8±10.4) with extra-temporal lobe epilepsy (XLE) and 20 normal controls (10 women; mean age 35.6±8.8) were included in the study. Serum levels of IL-1β, IL-6 and IL-1Ra of the TLE, XLE groups in inter-ictal period and of the normal control group were compared. RESULTS: All three cytokine levels are found to be significantly elevated in epilepsy patients when compared to controls (p<0.05). In TLE group, IL-1β serum levels were significantly higher than in the XLE group (p<0001). CONCLUSION: The major findings in our study were increased levels of IL-1β, IL-6 and IL-1Ra in epileptic patients and high levels of IL-1β in TLE group. Our results support the existence of a chronic inflammatory state in epileptic patients.
PURPOSE: There is now extensive evidence to support the involvement of inflammation in the course of epileptic seizures. Seizure-induced changes in serum IL-1β, IL-6 and IL-1Ra levels are reported in several studies. Serum cytokine levels may also be disturbed in inter-ictal period due to seizure activity. METHODS: Twenty-one patients (12 women; mean age 35±12.3) with temporal lobe epilepsy (TLE), 17 patients (8 women; mean age 31.8±10.4) with extra-temporal lobe epilepsy (XLE) and 20 normal controls (10 women; mean age 35.6±8.8) were included in the study. Serum levels of IL-1β, IL-6 and IL-1Ra of the TLE, XLE groups in inter-ictal period and of the normal control group were compared. RESULTS: All three cytokine levels are found to be significantly elevated in epilepsypatients when compared to controls (p<0.05). In TLE group, IL-1β serum levels were significantly higher than in the XLE group (p<0001). CONCLUSION: The major findings in our study were increased levels of IL-1β, IL-6 and IL-1Ra in epilepticpatients and high levels of IL-1β in TLE group. Our results support the existence of a chronic inflammatory state in epilepticpatients.
Authors: Annamaria Vezzani; Robert S Fujinami; H Steve White; Pierre-Marie Preux; Ingmar Blümcke; Josemir W Sander; Wolfgang Löscher Journal: Acta Neuropathol Date: 2015-09-30 Impact factor: 17.088
Authors: Anna A Karan; Yulia S Spivak; Konstantin A Gerasimov; Elena M Suleymanova; Maria N Volobueva; Alexey A Kvichansky; Lyudmila V Vinogradova; Alexey P Bolshakov Journal: Mol Neurobiol Date: 2021-04-27 Impact factor: 5.590