Ashwini Budrukkar1, Lavanya Gurram2, Ritu Raj Upreti3, Anusheel Munshi2, Rakesh Jalali2, Rajendra Badwe4, Vani Parmar4, Tanuja Shet5, Sudeep Gupta6, Tabassum Wadasadawala2, Rajiv Sarin2. 1. Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. Electronic address: ashwininb@yahoo.com. 2. Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. 3. Department of Medical Physics, Tata Memorial Hospital, Mumbai, India. 4. Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India. 5. Department of Pathology, Tata Memorial Hospital, Mumbai, India. 6. Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.
Abstract
PURPOSE: To study the clinical outcomes of women with early breast cancer (EBC) treated with accelerated partial breast irradiation (APBI) with multicatheter interstitial brachytherapy (MIB) using 3 dimensional computerized tomography (3DCT) based planning. MATERIALS AND METHODS: During August 2005 to January 2013, 140 women with EBC were treated prospectively with APBI using high dose rate (HDR) MIB. After 3DCT based planning patients were treated to a dose of 34 Gy/10 #/1 week with bid regimen. RESULTS: Median age was 57 years and tumor size 2 cm (range: 0.6-3.2 cm). Infiltrating duct carcinoma (IDC) was the most common histology; grade III tumors were seen in 82%. Median dose homogeneity index (DHI) was 0.76 (range: 0.49-0.85). The median coverage index (CI) of the cavity was 90% (61.4-100) and 80.5% (53.6-97.4) for planning target volume (PTV). Median follow up was 60 months (1-102 months). The 5 and 7 year local control rates (LC) were 97% and 92% respectively. Her2 positivity was the only prognostic factor which had an adverse impact on LC (p=0.01). Five and 7 year disease free survival (DFS) and overall survival (OAS) were 93%, 84%, 97.5% and 89% respectively. Good to excellent cosmetic outcomes at last follow up were seen in 87 (77%) women. CONCLUSIONS: 3DCT based MIB results in excellent long term outcomes and good to excellent cosmesis. Her2 positivity has an adverse impact on LC rates.
PURPOSE: To study the clinical outcomes of women with early breast cancer (EBC) treated with accelerated partial breast irradiation (APBI) with multicatheter interstitial brachytherapy (MIB) using 3 dimensional computerized tomography (3DCT) based planning. MATERIALS AND METHODS: During August 2005 to January 2013, 140 women with EBC were treated prospectively with APBI using high dose rate (HDR) MIB. After 3DCT based planning patients were treated to a dose of 34 Gy/10 #/1 week with bid regimen. RESULTS: Median age was 57 years and tumor size 2 cm (range: 0.6-3.2 cm). Infiltrating duct carcinoma (IDC) was the most common histology; grade III tumors were seen in 82%. Median dose homogeneity index (DHI) was 0.76 (range: 0.49-0.85). The median coverage index (CI) of the cavity was 90% (61.4-100) and 80.5% (53.6-97.4) for planning target volume (PTV). Median follow up was 60 months (1-102 months). The 5 and 7 year local control rates (LC) were 97% and 92% respectively. Her2 positivity was the only prognostic factor which had an adverse impact on LC (p=0.01). Five and 7 year disease free survival (DFS) and overall survival (OAS) were 93%, 84%, 97.5% and 89% respectively. Good to excellent cosmetic outcomes at last follow up were seen in 87 (77%) women. CONCLUSIONS: 3DCT based MIB results in excellent long term outcomes and good to excellent cosmesis. Her2 positivity has an adverse impact on LC rates.
Authors: Bharath Rangarajan; Tanuja Shet; Tabassum Wadasadawala; Nita S Nair; R Madhu Sairam; Sachin S Hingmire; Jyoti Bajpai Journal: South Asian J Cancer Date: 2016 Jul-Sep
Authors: Jamil A Aliyev; Isa H Isayev; Kamal S Akbarov; Samir S Qurbanov; Ruslan R Huseynov; Nigar S Aliyeva Journal: J Contemp Brachytherapy Date: 2017-04-13