INTRODUCTION: Maternal obesity has long-term consequences for the offspring's later health, including an increased risk of type 2 diabetes and cardiovascular disease. The underlying mechanisms explaining these associations are, however, not fully understood. METHODS: A total of 2003 individuals from the Helsinki Birth Cohort Study born 1934-44, underwent measurements of body size, body composition, and clinical characteristics at a mean age of 62 years. Data on maternal anthropometry were available from hospital records. RESULTS: Maternal BMI was positively associated with BMI in the offspring. Higher maternal BMI was associated with less favorable body composition in the offspring. There was a significant interaction between birth weight and maternal BMI on offspring body fat percentage (P for interaction 0.003). In mothers with low BMI, a higher offspring birth weight was associated with lower fat percentage, while among those with maternal BMI in the highest fourth, higher offspring birth weight predicted higher body fat percentage. DISCUSSION: Our findings suggest that a disadvantageous body composition is programmed in early life. This may in part underlie the association between maternal obesity and later cardio-metabolic health of the offspring. These findings support the importance of prevention of overweight in women of child-bearing age.
INTRODUCTION:Maternal obesity has long-term consequences for the offspring's later health, including an increased risk of type 2 diabetes and cardiovascular disease. The underlying mechanisms explaining these associations are, however, not fully understood. METHODS: A total of 2003 individuals from the Helsinki Birth Cohort Study born 1934-44, underwent measurements of body size, body composition, and clinical characteristics at a mean age of 62 years. Data on maternal anthropometry were available from hospital records. RESULTS: Maternal BMI was positively associated with BMI in the offspring. Higher maternal BMI was associated with less favorable body composition in the offspring. There was a significant interaction between birth weight and maternal BMI on offspring body fat percentage (P for interaction 0.003). In mothers with low BMI, a higher offspring birth weight was associated with lower fat percentage, while among those with maternal BMI in the highest fourth, higher offspring birth weight predicted higher body fat percentage. DISCUSSION: Our findings suggest that a disadvantageous body composition is programmed in early life. This may in part underlie the association between maternal obesity and later cardio-metabolic health of the offspring. These findings support the importance of prevention of overweight in women of child-bearing age.
Authors: N Kaseva; M Vääräsmäki; H-M Matinolli; M Sipola-Leppänen; M Tikanmäki; K Heinonen; A Lano; D Wolke; S Andersson; M-R Järvelin; K Räikkönen; J G Eriksson; E Kajantie Journal: Int J Obes (Lond) Date: 2017-11-17 Impact factor: 5.095
Authors: Keith M Godfrey; Rebecca M Reynolds; Susan L Prescott; Moffat Nyirenda; Vincent W V Jaddoe; Johan G Eriksson; Birit F P Broekman Journal: Lancet Diabetes Endocrinol Date: 2016-10-12 Impact factor: 32.069
Authors: Isabelle Schoppa; Asya Lyass; Nancy Heard-Costa; Sarah D de Ferranti; Caroline Fox; Matthew W Gillman; Ralph D'Agostino; Daniel Levy; Michael M Mendelson Journal: Obesity (Silver Spring) Date: 2018-11-25 Impact factor: 5.002
Authors: Linda S B Johnson; Minna Salonen; Eero Kajantie; David Conen; Jeff S Healey; Clive Osmond; Johan G Eriksson Journal: J Am Heart Assoc Date: 2017-06-25 Impact factor: 5.501
Authors: Anne M van Oers; Meike A Q Mutsaerts; Jan M Burggraaff; Walter K H Kuchenbecker; Denise A M Perquin; Carolien A M Koks; Ron van Golde; Eugenie M Kaaijk; Frank J Broekmans; Jan Peter de Bruin; Fulco van der Veen; Annemiek W Nap; Ed T C M Gondrie; Ben W J Mol; Henk Groen; Annemieke Hoek Journal: PLoS One Date: 2018-03-28 Impact factor: 3.240