Letícia Rozeno Pessoa1, Thaís de Salgado Rêgo2, Louise da Silva Asht3, Igor Cabral Coutinho do Rêgo Monteiro4, Rodrigo Soares Fortunato5, Márcia Barreto da Silva Feijó6, André Manoel Correia-Santos7, Carlos Alberto Soares da Costa8, Gilson Teles Boaventura9. 1. Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. leticiapessoa@id.uff.br. 2. Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. thais.nutricionista@ymail.com. 3. Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. lou_asth@hotmail.com. 4. Laboratory of Molecular Radiobiology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro.. igorccdrm@hotmail.com. 5. Laboratory of Molecular Radiobiology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro.. rsfortunato@yahoo.com.br. 6. Bromatology Laboratory, College of Pharmacy, Federal Fluminense University, Niterói. Brazil.. marciabfeijo@globo.com. 7. Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. andremcorreia@gmail.com. 8. Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. carlosnut@ibest.com.br. 9. Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. gilsontb@gmail.com.
Abstract
INTRODUCTION: Liver disease as a major cause of mortality in patients with diabetes mellitus. There is a interest to investigate the hypolipidemic properties of yam. The goal was assess the role of Brazilian yam (Dioscorea bulbifera) on serum and hepatic levels of triglycerides and cholesterol, in female diabetic rats. METHODS: The rats were divided into three groups: Control (C), Diabetic (DM); Diabetic Yam (DMY), treated with diet containing 25g/100g of yam flour. After 5 weeks of experiment, glucose, insulin, gonadal fat and liver mass were evaluated. Serum and liver concentrations of triglycerides and cholesterol concentrations were quantified. Total liver thiols were determined. RESULTS: After the 5 weeks, experimental groups shower (P < 0.05): Lower body mass; lower serum insulin; higher food intake and higher blood glucose concentration. DMY (vs. DM) group showed (P < 0.05): Lower blood glucose; higher gonadal fat mass; lower serum and hepatic triglycerides; higher hepatic cholesterol and thiols concentrations. DMY (vs. C) group showed: Similar serum and hepatic triglycerides and hepatic thiols. CONCLUSIONS: Brazilian yam (Dioscorea bulbifera) alleviated the consequences of the experimental diabetic disease, suggesting protection to hypertriglyceridemia and lipid peroxidation. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
INTRODUCTION:Liver disease as a major cause of mortality in patients with diabetes mellitus. There is a interest to investigate the hypolipidemic properties of yam. The goal was assess the role of Brazilian yam (Dioscorea bulbifera) on serum and hepatic levels of triglycerides and cholesterol, in female diabeticrats. METHODS: The rats were divided into three groups: Control (C), Diabetic (DM); Diabetic Yam (DMY), treated with diet containing 25g/100g of yam flour. After 5 weeks of experiment, glucose, insulin, gonadal fat and liver mass were evaluated. Serum and liver concentrations of triglycerides and cholesterol concentrations were quantified. Total liver thiols were determined. RESULTS: After the 5 weeks, experimental groups shower (P < 0.05): Lower body mass; lower serum insulin; higher food intake and higher blood glucose concentration. DMY (vs. DM) group showed (P < 0.05): Lower blood glucose; higher gonadal fat mass; lower serum and hepatic triglycerides; higher hepatic cholesterol and thiols concentrations. DMY (vs. C) group showed: Similar serum and hepatic triglycerides and hepatic thiols. CONCLUSIONS: Brazilian yam (Dioscorea bulbifera) alleviated the consequences of the experimental diabetic disease, suggesting protection to hypertriglyceridemia and lipid peroxidation. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Aarti N Narkhede; Suresh D Jagtap; Pallavi S Nirmal; Shital A Giramkar; Bhagyashri E Nagarkar; Omkar P Kulkarni; Abhay M Harsulkar Journal: BMC Complement Altern Med Date: 2016-01-22 Impact factor: 3.659