Ana Cristina Rodríguez-Dehli1, Isolina Riaño Galán2, Ana Fernández-Somoano3, Eva María Navarrete-Muñoz4, Mercedes Espada5, Jesús Vioque4, Adonina Tardón3. 1. Servicio de Pediatría, Hospital San Agustín, Avilés, Asturias.. crdehli@yahoo.es. 2. Servicio de Pediatría, Hospital San Agustín, Avilés, Asturias. CIBER en Epidemiología y Salud Pública (CIBERESP).. crdehli@yahoo.es. 3. Servicio de Medicina Preventiva, Universidad de Oviedo, Asturias. CIBER en Epidemiología y Salud Pública (CIBERESP).. crdehli@yahoo.es. 4. CIBER en Epidemiología y Salud Pública (CIBERESP). Departamento de Salud Pública, Universidad Miguel Hernández, Elche, Alicante.. crdehli@yahoo.es. 5. Unidad de Química Clínica, Salud Pública Laboratorio de Bilbao, Euskadi. España.. crdehli@yahoo.es.
Abstract
BACKGROUND AND OBJECTIVES: The vitamin D deficiency during pregnancy has been associated with adverse events during pregnancy and the postnatal child development. In this study we examined plasma levels of vitamin D [25(OH)D3] and factors associated with plasma deficiency and insufficiency in pregnant women in northern Spain. METHODS: We analyzed data from 453 pregnant women participating in the INMA-Asturias cohort in which was determined 25(OH)D3 by high resolution liquid chromatography.Dietary intake of vitamin D was estimated through a food frequency validated questionnaire. We estimated the prevalence of deficiency [25(OH)D3 <20 ng/ml] and insufficiency [20 to 29.9 ng / ml] of vitamin D and analyzed the distribution of 25(OH)D3 per month extraction and other factors. RESULTS: The mean concentration of 25(OH)D3 was 27.7 ng/ml (range 6.4 to 69.5). 27.4% of pregnant women had deficient levels and 35.3% inssuficient. Levels of 25(OH)D3 were higher in the summer months (median 34.1 ng/ml). There was a higher percentage of deficiency in pregnant women with overweight/obesity (34.5%) and under 25 years (47.8%). The average daily intake of vitamin D was 5.48 mg / day (SD 2.82 range 1.09 to 32.52).Intake during the months of October to May was associated with levels of 25(OH)D3. 8.6% reported taking supplements of vitamin D. CONCLUSIONS: We detected a high proportion of pregnant women with deficient or insufficient vitamin D levels, especially in the months of October to May, in pregnant women with overweight and obesity, and the youngest. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
BACKGROUND AND OBJECTIVES: The vitamin D deficiency during pregnancy has been associated with adverse events during pregnancy and the postnatal child development. In this study we examined plasma levels of vitamin D [25(OH)D3] and factors associated with plasma deficiency and insufficiency in pregnant women in northern Spain. METHODS: We analyzed data from 453 pregnant women participating in the INMA-Asturias cohort in which was determined 25(OH)D3 by high resolution liquid chromatography.Dietary intake of vitamin D was estimated through a food frequency validated questionnaire. We estimated the prevalence of deficiency [25(OH)D3 <20 ng/ml] and insufficiency [20 to 29.9 ng / ml] of vitamin D and analyzed the distribution of 25(OH)D3 per month extraction and other factors. RESULTS: The mean concentration of 25(OH)D3 was 27.7 ng/ml (range 6.4 to 69.5). 27.4% of pregnant women had deficient levels and 35.3% inssuficient. Levels of 25(OH)D3 were higher in the summer months (median 34.1 ng/ml). There was a higher percentage of deficiency in pregnant women with overweight/obesity (34.5%) and under 25 years (47.8%). The average daily intake of vitamin D was 5.48 mg / day (SD 2.82 range 1.09 to 32.52).Intake during the months of October to May was associated with levels of 25(OH)D3. 8.6% reported taking supplements of vitamin D. CONCLUSIONS: We detected a high proportion of pregnant women with deficient or insufficientvitamin D levels, especially in the months of October to May, in pregnant women with overweight and obesity, and the youngest. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.