Literature DB >> 2579392

Neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta: effects of pimozide, penfluridol, chlorpromazine, and haloperidol.

S F Flaim, M D Brannan, S C Swigart, M M Gleason, L D Muschek.   

Abstract

This study was designed to determine whether neuroleptic drugs have calcium channel blocking activity in isolated rings of rabbit thoracic aorta. The results confirm previous findings that pimozide and penfluridol are calcium channel blockers. However, the data do not support the conclusion that these agents are selective for the voltage-sensitive calcium channel. The results also show that both haloperidol and chlorpromazine (which represent different classes of neuroleptic drugs) are also calcium channel blockers in vascular smooth muscle.

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Year:  1985        PMID： 2579392      PMCID： PMC397230          DOI： 10.1073/pnas.82.4.1237

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

1.  A calmodulin-like ca receptor in the ca channel.

Authors:  J D Johnson
Journal:  Biophys J       Date:  1984-01       Impact factor: 4.033

2.  Inhibition of Ca2+-activated tension and myosin light chain phosphorylation in skinned smooth muscle strips by the phenothiazines.

Authors:  P Cassidy; P E Hoar; W G Kerrick
Journal:  Pflugers Arch       Date:  1980-09       Impact factor: 3.657

3.  Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.

Authors:  W C Prozialeck; B Weiss
Journal:  J Pharmacol Exp Ther       Date:  1982-09       Impact factor: 4.030

4.  Effects of the calmodulin antagonist, fluphenazine, on phosphorylation of myosin and phosphorylase in intact smooth muscle.

Authors:  P J Silver; J T Stull
Journal:  Mol Pharmacol       Date:  1983-05       Impact factor: 4.436

5.  Evidence for two separated Ca2+ pathways in smooth muscle plasmalemma.

Authors:  K D Meisheri; O Hwang; C van Breemen
Journal:  J Membr Biol       Date:  1981-03-15       Impact factor: 1.843

Review 6.  Sites of action of Ca2+ channel inhibitors.

Authors:  R A Janis; A Scriabine
Journal:  Biochem Pharmacol       Date:  1983-12-01       Impact factor: 5.858

7.  The effects of amrinone on contractility, Ca2+ uptake and cAMP in smooth muscle.

Authors:  K D Meisheri; R F Palmer; C Van Breemen
Journal:  Eur J Pharmacol       Date:  1980-01-25       Impact factor: 4.432

8.  Determination of the free-energy coupling for binding of calcium ions and troponin I to calmodulin.

Authors:  C H Keller; B B Olwin; D C LaPorte; D R Storm
Journal:  Biochemistry       Date:  1982-01-05       Impact factor: 3.162

9.  Effects of various calmodulin antagonists on contraction of rabbit aortic strips.

Authors:  M Asano; Y Suzuki; H Hidaka
Journal:  J Pharmacol Exp Ther       Date:  1982-01       Impact factor: 4.030

10.  Mechanism of 5-HT contraction in isolated bovine ventricular coronary arteries. Evidence for transient receptor-operated calcium influx channels.

Authors:  P H Ratz; S F Flaim
Journal:  Circ Res       Date:  1984-02       Impact factor: 17.367
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  6 in total

Review 1.  Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.

Authors:  Anne Marie R Yunker
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

2.  Inhibition of cyclosporin A/FK506 resistant, lymphokine-induced T-cell activation by phenothiazine derivatives.

Authors:  M Schleuning; V Brumme; W Wilmanns
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-07       Impact factor: 3.000

3.  Increased susceptibility and reduced phytoalexin accumulation in drought-stressed peanut kernels challenged with Aspergillus flavus.

Authors:  H R Wotton; R N Strange
Journal:  Appl Environ Microbiol       Date:  1987-02       Impact factor: 4.792

4.  Angiotensin II-induced increase in slowly exchanging 45Ca2+ in relation to contractile responses of rat and guinea-pig aorta.

Authors:  P N van Heiningen; H D Batink; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-07       Impact factor: 3.000

5.  Effects of nimodipine on the discriminative stimulus properties of d-amphetamine in rats.

Authors:  P Nencini; W L Woolverton
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

6.  Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment.

Authors:  Pareesa Kamgar-Dayhoff; Tinatin I Brelidze
Journal:  Oncotarget       Date:  2021-07-06
  6 in total

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