| Literature DB >> 25793479 |
Waidi Folorunso Sule1, Daniel Oladimeji Oluwayelu, Rahamon Akinyele Moshood Adedokun, Nurudeen Rufai, Fiona McCracken, Karen L Mansfield, Nicholas Johnson.
Abstract
To investigate exposure of Nigerian horses to West Nile virus (WNV), we determined the seroprevalence rate of anti-WNV antibody in a cohort of 145 horses. Serum samples were collected from three locations in southwestern Nigeria between October, 2011, and July, 2012. The horses were asymptomatic and unvaccinated against WNV at the time of sampling. All sera were tested using a competition enzyme-linked immmunosorbent assay (ELISA) and by an immunoglobulin M (IgM)-specific ELISA. High rates of anti-WNV antibody prevalence were observed in all locations with a mean level of 90.3% (95% confidence interval 84.3-94.6%). None of the horses had detectable anti-WNV IgM. This is the first ELISA-based report of WNV seroprevalence in Nigerian horses and suggests that WNV is enzootic in the study areas, indicating a potential risk of infection in humans and animals.Entities:
Keywords: Anti-West Nile virus antibody; ELISA; Horse; Nigeria; Seroprevalence
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Year: 2015 PMID： 25793479 PMCID： PMC4369928 DOI： 10.1089/vbz.2014.1706
Source DB: PubMed Journal: Vector Borne Zoonotic Dis ISSN： 1530-3667 Impact factor: 2.133