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Literature DB >> 21367890

Keratinocytes are cell targets of West Nile virus in vivo.

Pei-Yin Lim¹, Melissa J Behr, Chrystal M Chadwick, Pei-Yong Shi, Kristen A Bernard.

Abstract

West Nile virus (WNV) replicates in the skin; however, cell targets in the skin have not been identified. In the current studies, WNV infected the epidermis and adnexal glands of mouse skin, and the epidermal cells were identified as keratinocytes by double labeling for WNV antigen and keratin 10. Inoculation of mice with WNV replicon particles resulted in high levels of replication in the skin, suggesting that keratinocytes are an initial target of WNV. In addition, primary keratinocytes produced infectious virus in vitro. In conclusion, keratinocytes are cell targets of WNV in vivo and may play an important role in pathogenesis.

Entities: Disease Species

Mesh：

Substances：

Year: 2011 PMID： 21367890 PMCID： PMC3126165 DOI： 10.1128/JVI.02692-10

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

23 in total

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Review 5. Epidermal "turnover time"--a re-examination.

Authors: K M Halprin
Journal: Br J Dermatol Date: 1972-01 Impact factor: 9.302

6. Dengue virus inoculation to human skin explants: an effective approach to assess in situ the early infection and the effects on cutaneous dendritic cells.

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Authors: Arno Wünschmann; Jan Shivers; Jeff Bender; Larry Carroll; Susan Fuller; Miguel Saggese; Arnaud van Wettere; Pat Redig
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8. Infectious cDNA clone of the epidemic west nile virus from New York City.

Authors: Pei-Yong Shi; Mark Tilgner; Michael K Lo; Kim A Kent; Kristen A Bernard
Journal: J Virol Date: 2002-06 Impact factor: 5.103

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Journal: Vet Pathol Date: 1995-11 Impact factor: 2.221

10. Dynamics of keratinocytes in vivo using HO labeling: a sensitive marker of epidermal proliferation state.

Authors: Elaine A Hsieh; Christine M Chai; Benito O de Lumen; Richard A Neese; Marc K Hellerstein
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Review 6. Regulation of cell survival and death during Flavivirus infections.

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Journal: World J Biol Chem Date: 2014-05-26

7. West Nile Virus Infection Blocks Inflammatory Response and T Cell Costimulatory Capacity of Human Monocyte-Derived Dendritic Cells.

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