Literature DB >> 25790788

Aqueous hydrotrope: an efficient and reusable medium for a green one-pot, diversity-oriented synthesis of quinazolinone derivatives.

Amol Patil1, Madhuri Barge, Gajanan Rashinkar, Rajashri Salunkhe.   

Abstract

A library of quinazolinones was prepared by the one-pot three-component reaction of isatoic anhydride, ammonium salts/amines, and various electrophiles using aqueous hydrotropic solution as an efficient, economical, reusable, and green medium giving good to excellent yields of products in very short time. The method offers a versatile way for the development of diversity-oriented synthesis of quinazolinones.

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Year:  2015        PMID： 25790788     DOI： 10.1007/s11030-015-9580-8

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  15 in total

1.  A planning strategy for diversity-oriented synthesis.

Authors:  Martin D Burke; Stuart L Schreiber
Journal:  Angew Chem Int Ed Engl       Date:  2004-01       Impact factor: 15.336

2.  Organic reactions in aqueous media with a focus on carbon-carbon bond formations: a decade update.

Authors:  Chao-Jun Li
Journal:  Chem Rev       Date:  2005-08       Impact factor: 60.622

3.  Organic chemistry in water.

Authors:  Chao-Jun Li; Liang Chen
Journal:  Chem Soc Rev       Date:  2005-11-21       Impact factor: 54.564

4.  Green chemistry: principles and practice.

Authors:  Paul Anastas; Nicolas Eghbali
Journal:  Chem Soc Rev       Date:  2009-11-20       Impact factor: 54.564

5.  Palladium-catalyzed cyclocarbonylation of o-iodoanilines with heterocumulenes: regioselective preparation of 4(3H)-quinazolinone derivatives

Authors: 
Journal:  J Org Chem       Date:  2000-05-09       Impact factor: 4.354

6.  Synthesis of 5-substituted quinazolines as potential antimalarial agents.

Authors:  W T Ashton; J B Hynes
Journal:  J Med Chem       Date:  1973-11       Impact factor: 7.446

7.  Synthesis of 2,3-dihydroquinazolin-4(1H)-ones by three-component coupling of isatoic anhydride, amines, and aldehydes catalyzed by magnetic Fe(3)O(4) nanoparticles in water.

Authors:  Zhan-Hui Zhang; Hong-Yan Lü; Shu-Hong Yang; Jian-Wu Gao
Journal:  J Comb Chem       Date:  2010-09-13

8.  Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors.

Authors:  Masahiko Hayakawa; Hiroyuki Kaizawa; Hiroyuki Moritomo; Tomonobu Koizumi; Takahide Ohishi; Minoru Okada; Mitsuaki Ohta; Shin-ichi Tsukamoto; Peter Parker; Paul Workman; Mike Waterfield
Journal:  Bioorg Med Chem       Date:  2006-07-11       Impact factor: 3.641

9.  Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: search for anticancer agent.

Authors:  Malleshappa N Noolvi; Harun M Patel; Varun Bhardwaj; Ankit Chauhan
Journal:  Eur J Med Chem       Date:  2011-03-15       Impact factor: 6.514

Review 10.  Multicomponent reactions for the synthesis of pyrroles.

Authors:  Verónica Estévez; Mercedes Villacampa; J Carlos Menéndez
Journal:  Chem Soc Rev       Date:  2010-07-05       Impact factor: 54.564
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  3 in total

Review 1.  2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design.

Authors:  Mariateresa Badolato; Francesca Aiello; Nouri Neamati
Journal:  RSC Adv       Date:  2018-06-07       Impact factor: 4.036

2.  Hydrotropic Solubilization of Lipophilic Drugs for Oral Delivery: The Effects of Urea and Nicotinamide on Carbamazepine Solubility-Permeability Interplay.

Authors:  Avital Beig; David Lindley; Jonathan M Miller; Riad Agbaria; Arik Dahan
Journal:  Front Pharmacol       Date:  2016-10-25       Impact factor: 5.810

3.  Synthesis, Antiproliferative, and Antioxidant Evaluation of 2-Pentylquinazolin-4(3H)-one(thione) Derivatives with DFT Study.

Authors:  Amira A El-Sayed; Mahmoud F Ismail; Abd El-Galil E Amr; Ahmed M Naglah
Journal:  Molecules       Date:  2019-10-21       Impact factor: 4.411
  3 in total

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