Literature DB >> 2579001

Two-stage hormonal control of type IV collagen mRNA levels during differentiation of F9 teratocarcinoma cells.

K R Marotti, G D Brown, S Strickland.   

Abstract

A cDNA clone related to mouse Type IV collagen has been prepared from F9 teratocarcinoma cells induced to differentiate with retinoic acid and dibutyryl-cAMP. This cDNA clone has been used to investigate the regulation of Type IV collagen mRNA during differentiation. The level of this mRNA is very low in untreated F9 cells, increases substantially after treatment of the cells with retinoic acid, and is further increased by addition of dibutyryl-cAMP. In contrast, dibutyryl-cAMP has no effect on the mRNA level in cells that have not been previously exposed to retinoic acid. These results demonstrate that these two compounds regulate in a sequential manner the steady-state level of Type IV collagen mRNA. This cDNA clone should allow a detailed examination of the mechanism of the two-stage regulation of collagen expression by retinoids and cyclic AMP.

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Year:  1985        PMID： 2579001     DOI： 10.1016/0012-1606(85)90005-3

Source DB:  PubMed          Journal:  Dev Biol        ISSN： 0012-1606            Impact factor:   3.582


  9 in total

1.  Positive elements in the laminin gamma 1 gene synergize to activate high level transcription during cellular differentiation.

Authors:  H S Chang; N B Kim; S L Phillips
Journal:  Nucleic Acids Res       Date:  1996-04-01       Impact factor: 16.971

2.  Competition studies with repressors and activators of viral enhancer function in F9 mouse embryonal carcinoma cells.

Authors:  M J Sleigh; T J Lockett; J Kelly; D Lewy
Journal:  Nucleic Acids Res       Date:  1987-05-26       Impact factor: 16.971

3.  Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha).

Authors:  N J Brand; M Petkovich; P Chambon
Journal:  Nucleic Acids Res       Date:  1990-12-11       Impact factor: 16.971

4.  c-myc regulation during retinoic acid-induced differentiation of F9 cells is posttranscriptional and associated with growth arrest.

Authors:  M Dean; R A Levine; J Campisi
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272

5.  Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids.

Authors:  H Y Lee; H Y Chung; K H Kim; J J Lee; K W Kim
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

6.  Induction of thrombospondin 1 by retinoic acid is important during differentiation of neuroblastoma cells.

Authors:  V P Castle; X Ou; S O'Shea; V M Dixit
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

7.  Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers.

Authors:  J H Segars; T Nagata; V Bours; J A Medin; G Franzoso; J C Blanco; P D Drew; K G Becker; J An; T Tang
Journal:  Mol Cell Biol       Date:  1993-10       Impact factor: 4.272

8.  The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element.

Authors:  G Vasios; S Mader; J D Gold; M Leid; Y Lutz; M P Gaub; P Chambon; L Gudas
Journal:  EMBO J       Date:  1991-05       Impact factor: 11.598

9.  Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11.

Authors:  I J Mason; D Murphy; M Münke; U Francke; R W Elliott; B L Hogan
Journal:  EMBO J       Date:  1986-08       Impact factor: 11.598
  9 in total

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