BACKGROUND/ PURPOSE: Single-nucleotide polymorphisms (SNPs) around the interferon lambda 3 (IFNL3; also known as interleukin 28B; IL28B) gene are associated with spontaneous hepatitis C virus (HCV) clearance. Interferon lambda 4 (IFNL4).ss469415590, in linkage disequilibrium (LD) with IFNL3.rs12979860 among the Caucasian population, has recently been identified as a potential functional variant. Our objective was to assess the LD between IFNL3.rs12979860 and IFNL4.ss469415590 and to compare their effect on the outcome of HCV infection among Egyptians, mainly infected with HCV genotype 4. METHODS: One-hundred and eighty-five Egyptian HCV patients (77 spontaneous resolvers and 108 chronic subjects), and 122 healthy controls were genotyped for both IL28B.rs12979860 and IFNL4.ss469415590. Logistic regression models including factors with univariate association with the outcome of infection were calculated for each genetic marker. The LD was also calculated for the 122 healthy controls. RESULTS: The CC genotype of IFNL3.rs12979860 was more frequent among individuals with HCV spontaneous resolution than among those with chronic infection (57 vs. 27%; adjusted OR 3.84; 95% CI 2.02-7.30; p < 0.0001). Also, the TT/TT genotype of IFNL4.ss469415590 was more frequent among individuals with spontaneous resolution (49 vs. 20%; adjusted OR 4.17; 95% CI 2.12-8.19; p < 0.0001). Both markers were in LD (D' = 0.96; r (2) = 0.84). CONCLUSION: The IFNL3.rs12979860 and IFNL4.ss469415590 variants have comparable effects on spontaneous resolution of HCV among Egyptians, for whom both markers are closely linked.
BACKGROUND/ PURPOSE: Single-nucleotide polymorphisms (SNPs) around the interferon lambda 3 (IFNL3; also known as interleukin 28B; IL28B) gene are associated with spontaneous hepatitis C virus (HCV) clearance. Interferon lambda 4 (IFNL4).ss469415590, in linkage disequilibrium (LD) with IFNL3.rs12979860 among the Caucasian population, has recently been identified as a potential functional variant. Our objective was to assess the LD between IFNL3.rs12979860 and IFNL4.ss469415590 and to compare their effect on the outcome of HCV infection among Egyptians, mainly infected with HCV genotype 4. METHODS: One-hundred and eighty-five Egyptian HCVpatients (77 spontaneous resolvers and 108 chronic subjects), and 122 healthy controls were genotyped for both IL28B.rs12979860 and IFNL4.ss469415590. Logistic regression models including factors with univariate association with the outcome of infection were calculated for each genetic marker. The LD was also calculated for the 122 healthy controls. RESULTS: The CC genotype of IFNL3.rs12979860 was more frequent among individuals with HCV spontaneous resolution than among those with chronic infection (57 vs. 27%; adjusted OR 3.84; 95% CI 2.02-7.30; p < 0.0001). Also, the TT/TT genotype of IFNL4.ss469415590 was more frequent among individuals with spontaneous resolution (49 vs. 20%; adjusted OR 4.17; 95% CI 2.12-8.19; p < 0.0001). Both markers were in LD (D' = 0.96; r (2) = 0.84). CONCLUSION: The IFNL3.rs12979860 and IFNL4.ss469415590 variants have comparable effects on spontaneous resolution of HCV among Egyptians, for whom both markers are closely linked.
Authors: Sayed Abdelwahab; Eman Rewisha; Mohamed Hashem; Maha Sobhy; Iman Galal; Walaa R Allam; Nabeil Mikhail; Gehan Galal; Mohamed El-Tabbakh; Samer S El-Kamary; Imam Waked; G Thomas Strickland Journal: Trans R Soc Trop Med Hyg Date: 2011-12-22 Impact factor: 2.184
Authors: Salim I Khakoo; Chloe L Thio; Maureen P Martin; Collin R Brooks; Xiaojiang Gao; Jacquie Astemborski; Jie Cheng; James J Goedert; David Vlahov; Margaret Hilgartner; Steven Cox; Ann-Margeret Little; Graeme J Alexander; Matthew E Cramp; Stephen J O'Brien; William M C Rosenberg; David L Thomas; Mary Carrington Journal: Science Date: 2004-08-06 Impact factor: 47.728
Authors: Brenna M Henn; Laura R Botigué; Simon Gravel; Wei Wang; Abra Brisbin; Jake K Byrnes; Karima Fadhlaoui-Zid; Pierre A Zalloua; Andres Moreno-Estrada; Jaume Bertranpetit; Carlos D Bustamante; David Comas Journal: PLoS Genet Date: 2012-01-12 Impact factor: 5.917
Authors: Federico Sánchez-Quinto; Laura R Botigué; Sergi Civit; Conxita Arenas; María C Avila-Arcos; Carlos D Bustamante; David Comas; Carles Lalueza-Fox Journal: PLoS One Date: 2012-10-17 Impact factor: 3.240
Authors: David L Thomas; Chloe L Thio; Maureen P Martin; Ying Qi; Dongliang Ge; Colm O'Huigin; Judith Kidd; Kenneth Kidd; Salim I Khakoo; Graeme Alexander; James J Goedert; Gregory D Kirk; Sharyne M Donfield; Hugo R Rosen; Leslie H Tobler; Michael P Busch; John G McHutchison; David B Goldstein; Mary Carrington Journal: Nature Date: 2009-10-08 Impact factor: 49.962
Authors: Paola Jocelan Scarin Provazzi; Livia Maria Gonçalves Rossi; Bruno Moreira Carneiro; Valeria Chamas Miura; Plinio Cesar Rodrigues Rosa; Lucas Rodrigues de Carvalho; Stephane Tereza Queiroz de Andrade; Roberta Maria Fachini; Rejane Maria Tommasini Grotto; Giovanni Faria Silva; Carlos Roberto Valêncio; Paulo Scarpelini Neto; José Antonio Cordeiro; Mauricio Lacerda Nogueira; Paula Rahal Journal: Braz J Microbiol Date: 2018-12-04 Impact factor: 2.476