Jana Figurová1, Ingrid Dravecká2, Martin Javorský3, Jana Petríková2, Ivica Lazúrová2. 1. 1st Department of Internal medicine, Medical faculty of P.J.Šafarik University Košice, Trieda SNP 1, 040 11, Košice, Slovakia. jana.angelovicova@gmail.com. 2. 1st Department of Internal medicine, Medical faculty of P.J.Šafarik University Košice, Trieda SNP 1, 040 11, Košice, Slovakia. 3. 4th Department of Internal medicine, Medical faculty of P.J.Šafarik University, Košice, Slovakia.
Abstract
OBJECTIVE: To investigate prevalence of vitamin D deficiency and its relation to clinical, anthropometrical, and biochemical findings in polycystic ovary syndrome (PCOS) and controls. DESIGN: Case-control prospective observational study. SETTINGS: Department of Internal medicine, L.P. University hospital. PATIENT(S): 99 PCOS women and 66 controls. MAIN OUTCOME MEASURE(S): 25-hydroxyvitamin D level (25(OH)D), anthropometric, endocrine, and metabolic parameters in both groups. RESULTS: There was no significant difference in 25(OH)D levels between PCOS women and controls (24.79 ± 10.77 vs 25.07 ± 10.14 ng/ml, p = 0.868) and also in the prevalence of 25(OH)D deficiency in both groups (80 vs 70 %; p = 0.138). Vitamin D-deficient PCOS patients had significantly higher body mass index (BMI), fasting insulin, and homeostasis model assessment-insulin resistance (median [quartiles]: 2.24 [1.38; 3.51] vs 1.23 [0.79; 1.66]; p< 0.05, age-and BMI-adjusted p = 0.036) and borderline higher glycemia (4.7 ± 0.5 vs 4.5 ± 0.4 mmol/l; p = 0.05; p_adj = 0.95) compared with vitamin D-deficient controls. PCOS women with metabolic syndrome (MS) had lower serum 25(OH)D compared with those without MS (20.6 ± 8.3 vs 25.9 ± 11.3 ng/ml, p = 0.049). 25(OH)D correlated positively with high-density lipoprotein cholesterol in all subjects (r = 0.159, p = 0.043) and negatively with luteinizing hormone/follicle-stimulating hormone ratio (r = - 0.211, p = 0.037). CONCLUSION: Insulin resistance and other metabolic abnormalities in PCOS women seem to be related to PCOS rather than to vitamin D deficiency.
OBJECTIVE: To investigate prevalence of vitamin D deficiency and its relation to clinical, anthropometrical, and biochemical findings in polycystic ovary syndrome (PCOS) and controls. DESIGN: Case-control prospective observational study. SETTINGS: Department of Internal medicine, L.P. University hospital. PATIENT(S): 99 PCOSwomen and 66 controls. MAIN OUTCOME MEASURE(S): 25-hydroxyvitamin D level (25(OH)D), anthropometric, endocrine, and metabolic parameters in both groups. RESULTS: There was no significant difference in 25(OH)D levels between PCOSwomen and controls (24.79 ± 10.77 vs 25.07 ± 10.14 ng/ml, p = 0.868) and also in the prevalence of 25(OH)D deficiency in both groups (80 vs 70 %; p = 0.138). Vitamin D-deficient PCOSpatients had significantly higher body mass index (BMI), fasting insulin, and homeostasis model assessment-insulin resistance (median [quartiles]: 2.24 [1.38; 3.51] vs 1.23 [0.79; 1.66]; p< 0.05, age-and BMI-adjusted p = 0.036) and borderline higher glycemia (4.7 ± 0.5 vs 4.5 ± 0.4 mmol/l; p = 0.05; p_adj = 0.95) compared with vitamin D-deficient controls. PCOSwomen with metabolic syndrome (MS) had lower serum 25(OH)D compared with those without MS (20.6 ± 8.3 vs 25.9 ± 11.3 ng/ml, p = 0.049). 25(OH)D correlated positively with high-density lipoprotein cholesterol in all subjects (r = 0.159, p = 0.043) and negatively with luteinizing hormone/follicle-stimulating hormone ratio (r = - 0.211, p = 0.037). CONCLUSION:Insulin resistance and other metabolic abnormalities in PCOSwomen seem to be related to PCOS rather than to vitamin D deficiency.
Entities:
Keywords:
Hyperandrogenism; Insulin resistance; Polycystic ovary syndrome; Vitamin D deficiency
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