Jin Ju Kim1, Young Min Choi2, Soo Jin Chae3, Kyu Ri Hwang4, Sang Ho Yoon5, Min Jeong Kim6, Sun Mie Kim6, Seung Yup Ku2, Seok Hyun Kim2, Jung Gu Kim7. 1. Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. ; The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. 2. The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. 3. Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, Korea. 4. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. ; Department of Obstetrics and Gynecology, Seoul Municipal Boramae Hospital, Seoul, Korea. 5. Department of Obstetrics and Gynecology, Graduate School of Medicine, Dongguk University, Seoul, Korea. 6. Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. 7. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE: TO INVESTIGATE: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group. METHODS: We recruited 38 women with PCOS using the Rotterdam criteria. A total of 109 premenopausal control women were matched with patients based on age and body mass index. Serum 25-hydroxy vitamin D concentrations less than 20 ng/mL were classified as frank vitamin D deficiency. Since vitamin D may play a significant role in metabolic disturbances in women with PCOS, correlations between clinical or metabolic parameters and vitamin D status were analyzed separately in patients and controls. RESULTS: Women with PCOS showed no differences in the level of 25-hydroxy vitamin D (19.6±6.6 ng/mL in patients vs. 20.1±7.4 ng/mL in controls, respectively, p=0.696) or prevalence of vitamin D deficiency (57.9% in patients vs. 56.5% in controls, respectively, p=0.880). In addition, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles in either PCOS patients or controls. CONCLUSION: Our study found no differences in the absolute level of serum vitamin D between PCOS patients and matched controls. Prevalence of vitamin D deficiency was equally common among both patients and controls. Additionally, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles, suggesting that the role of vitamin D in the pathogenesis of PCOS is not yet clear.
OBJECTIVE: TO INVESTIGATE: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group. METHODS: We recruited 38 women with PCOS using the Rotterdam criteria. A total of 109 premenopausal control women were matched with patients based on age and body mass index. Serum 25-hydroxy vitamin D concentrations less than 20 ng/mL were classified as frank vitamin D deficiency. Since vitamin D may play a significant role in metabolic disturbances in women with PCOS, correlations between clinical or metabolic parameters and vitamin D status were analyzed separately in patients and controls. RESULTS:Women with PCOS showed no differences in the level of 25-hydroxy vitamin D (19.6±6.6 ng/mL in patients vs. 20.1±7.4 ng/mL in controls, respectively, p=0.696) or prevalence of vitamin D deficiency (57.9% in patients vs. 56.5% in controls, respectively, p=0.880). In addition, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles in either PCOSpatients or controls. CONCLUSION: Our study found no differences in the absolute level of serum vitamin D between PCOSpatients and matched controls. Prevalence of vitamin D deficiency was equally common among both patients and controls. Additionally, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles, suggesting that the role of vitamin D in the pathogenesis of PCOS is not yet clear.
Entities:
Keywords:
Insulin resistance; Polycystic ovary syndrome; Vitamin D
Authors: Catharina Mattila; Paul Knekt; Satu Männistö; Harri Rissanen; Maarit A Laaksonen; Jukka Montonen; Antti Reunanen Journal: Diabetes Care Date: 2007-07-12 Impact factor: 19.112
Authors: Anastassios G Pittas; Bess Dawson-Hughes; Tricia Li; Rob M Van Dam; Walter C Willett; Joann E Manson; Frank B Hu Journal: Diabetes Care Date: 2006-03 Impact factor: 19.112
Authors: Jared P Reis; Denise von Mühlen; Donna Kritz-Silverstein; Deborah L Wingard; Elizabeth Barrett-Connor Journal: Diabetes Care Date: 2007-03-10 Impact factor: 19.112
Authors: H Selimoglu; C Duran; S Kiyici; C Ersoy; M Guclu; G Ozkaya; E Tuncel; E Erturk; S Imamoglu Journal: J Endocrinol Invest Date: 2009-10-09 Impact factor: 4.256
Authors: Jana Figurová; Ingrid Dravecká; Martin Javorský; Jana Petríková; Ivica Lazúrová Journal: Wien Klin Wochenschr Date: 2015-03-19 Impact factor: 1.704
Authors: Alice Y Chang; Antigoni Z Lalia; Gregory D Jenkins; Tumpa Dutta; Rickey E Carter; Ravinder J Singh; K Sreekumaran Nair Journal: Metabolism Date: 2017-03-08 Impact factor: 8.694
Authors: Michelle M Pacis; Chelsea N Fortin; Shvetha M Zarek; Sunni L Mumford; James H Segars Journal: J Assist Reprod Genet Date: 2014-12-30 Impact factor: 3.412
Authors: Yong Jin Kim; Yoon Young Kim; Da Young Song; Sang Hoon Lee; Chan Woo Park; Hoon Kim; Seung-Yup Ku Journal: Tissue Eng Regen Med Date: 2018-08-28 Impact factor: 4.169
Authors: Yoon Young Kim; Bo Bin Choi; Ji Won Lim; Yong Jin Kim; Sung Yob Kim; Seung-Yup Ku Journal: Tissue Eng Regen Med Date: 2018-08-18 Impact factor: 4.169
Authors: Christian Trummer; Stefan Pilz; Verena Schwetz; Barbara Obermayer-Pietsch; Elisabeth Lerchbaum Journal: Endocr Connect Date: 2018-02-15 Impact factor: 3.335