BACKGROUND: Quantification of the association between breastfeeding and breast cancer risk is still conflicting. Therefore, we conducted a meta-analysis to summarize the evidence from epidemiological studies of breastfeeding with the risk of breast cancer. MATERIALS AND METHODS: Pertinent studies were identified by a search of PubMed between January 1, 2008 and July 31, 2014. The random-effect model was used. Sensitivity analysis, subgroups analysis, and publication bias were conducted. RESULTS: Twenty-four articles with 27 studies involving 13,907 breast cancer cases were included in this meta-analysis. Pooled results suggested that breastfeeding was inversely [corrected] associated with the risk of breast cancer. The summary relative risk (RR) of breast cancer for the ever compared with never categories of breastfeeding was 0.613 (95% confidence interval [CI], 0.442-0.850). An inverse association was also found for the longest compared with the shortest categories of breastfeeding with the risk of breast cancer (RR=0.471; 95% CI, 0.368-0.602). No evidence of publication bias was found. CONCLUSIONS: Findings from this meta-analysis suggest that breastfeeding, particularly a longer duration of breastfeeding, was inversely associated with risk of breast cancer.
BACKGROUND: Quantification of the association between breastfeeding and breast cancer risk is still conflicting. Therefore, we conducted a meta-analysis to summarize the evidence from epidemiological studies of breastfeeding with the risk of breast cancer. MATERIALS AND METHODS: Pertinent studies were identified by a search of PubMed between January 1, 2008 and July 31, 2014. The random-effect model was used. Sensitivity analysis, subgroups analysis, and publication bias were conducted. RESULTS: Twenty-four articles with 27 studies involving 13,907 breast cancer cases were included in this meta-analysis. Pooled results suggested that breastfeeding was inversely [corrected] associated with the risk of breast cancer. The summary relative risk (RR) of breast cancer for the ever compared with never categories of breastfeeding was 0.613 (95% confidence interval [CI], 0.442-0.850). An inverse association was also found for the longest compared with the shortest categories of breastfeeding with the risk of breast cancer (RR=0.471; 95% CI, 0.368-0.602). No evidence of publication bias was found. CONCLUSIONS: Findings from this meta-analysis suggest that breastfeeding, particularly a longer duration of breastfeeding, was inversely associated with risk of breast cancer.
Authors: Meera Sangaramoorthy; Lisa M Hines; Gabriela Torres-Mejía; Amanda I Phipps; Kathy B Baumgartner; Anna H Wu; Jocelyn Koo; Sue A Ingles; Martha L Slattery; Esther M John Journal: Epidemiology Date: 2019-05 Impact factor: 4.822
Authors: Julia Becaria Coquet; Natalia Tumas; Alberto Ruben Osella; Matteo Tanzi; Isabella Franco; Maria Del Pilar Diaz Journal: Asian Pac J Cancer Prev Date: 2016-10-01
Authors: Seok Hun Jeong; Yoon Suk An; Ji-Yeob Choi; Boyoung Park; Daehee Kang; Min Hyuk Lee; Wonshik Han; Dong Young Noh; Keun-Young Yoo; Sue K Park Journal: J Prev Med Public Health Date: 2017-11