Meera Sangaramoorthy1, Lisa M Hines2, Gabriela Torres-Mejía3, Amanda I Phipps4,5, Kathy B Baumgartner6, Anna H Wu7, Jocelyn Koo1,8, Sue A Ingles7, Martha L Slattery9, Esther M John1,8,10. 1. From the Cancer Prevention Institute of California, Fremont, CA. 2. Department of Biology, University of Colorado at Colorado Springs, Colorado Springs, CO. 3. Instituto Nacional de Salud Pública, Population Health Research Center, Cuernavaca Morelos, Mexico. 4. Department of Epidemiology, University of Washington, Seattle, WA. 5. Epidemiology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA. 6. Department of Epidemiology and Population Health, School of Public Health & Information Sciences, James Graham Brown Cancer Center, University of Louisville, Louisville, KY. 7. Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA. 8. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA. 9. Department of Medicine, University of Utah, Salt Lake City, UT. 10. Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA.
Abstract
BACKGROUND: Data on breastfeeding and breast cancer risk are sparse and inconsistent for Hispanic women. METHODS: Pooling data for nearly 6,000 parous Hispanic women from four population-based studies conducted between 1995 and 2007 in the United States and Mexico, we examined the association of breastfeeding with risk of breast cancer overall and subtypes defined by estrogen receptor (ER) and progesterone receptor (PR) status, and the joint effects of breastfeeding, parity, and age at first birth. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression. RESULTS: Among parous Hispanic women, older age at first birth was associated with increased breast cancer risk, whereas parity was associated with reduced risk. These associations were found for hormone receptor positive (HR+) breast cancer only and limited to premenopausal women. Age at first birth and parity were not associated with risk of ER- and PR- breast cancer. Increasing duration of breastfeeding was associated with decreasing breast cancer risk (≥25 vs. 0 months: OR = 0.73; 95% CI = 0.60, 0.89; Ptrend = 0.03), with no heterogeneity by menopausal status or subtype. At each parity level, breastfeeding further reduced HR+ breast cancer risk. Additionally, breastfeeding attenuated the increase in risk of HR+ breast cancer associated with older age at first birth. CONCLUSIONS: Our findings suggest that breastfeeding is associated with reduced risk of both HR+ and ER- and PR- breast cancer among Hispanic women, as reported for other populations, and may attenuate the increased risk in women with a first pregnancy at older ages.
BACKGROUND: Data on breastfeeding and breast cancer risk are sparse and inconsistent for Hispanic women. METHODS: Pooling data for nearly 6,000 parous Hispanic women from four population-based studies conducted between 1995 and 2007 in the United States and Mexico, we examined the association of breastfeeding with risk of breast cancer overall and subtypes defined by estrogen receptor (ER) and progesterone receptor (PR) status, and the joint effects of breastfeeding, parity, and age at first birth. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression. RESULTS: Among parous Hispanic women, older age at first birth was associated with increased breast cancer risk, whereas parity was associated with reduced risk. These associations were found for hormone receptor positive (HR+) breast cancer only and limited to premenopausal women. Age at first birth and parity were not associated with risk of ER- and PR- breast cancer. Increasing duration of breastfeeding was associated with decreasing breast cancer risk (≥25 vs. 0 months: OR = 0.73; 95% CI = 0.60, 0.89; Ptrend = 0.03), with no heterogeneity by menopausal status or subtype. At each parity level, breastfeeding further reduced HR+ breast cancer risk. Additionally, breastfeeding attenuated the increase in risk of HR+ breast cancer associated with older age at first birth. CONCLUSIONS: Our findings suggest that breastfeeding is associated with reduced risk of both HR+ and ER- and PR- breast cancer among Hispanic women, as reported for other populations, and may attenuate the increased risk in women with a first pregnancy at older ages.
Authors: Martha L Slattery; Carol Sweeney; Sandra Edwards; Jennifer Herrick; Kathy Baumgartner; Roger Wolff; Maureen Murtaugh; Richard Baumgartner; Anna Giuliano; Tim Byers Journal: Breast Cancer Res Treat Date: 2007-03 Impact factor: 4.872
Authors: Esther M John; Alexander Miron; Gail Gong; Amanda I Phipps; Anna Felberg; Frederick P Li; Dee W West; Alice S Whittemore Journal: JAMA Date: 2007-12-26 Impact factor: 56.272
Authors: Erica T Warner; Graham A Colditz; Julie R Palmer; Ann H Partridge; Bernard A Rosner; Rulla M Tamimi Journal: Breast Cancer Res Treat Date: 2013-10-18 Impact factor: 4.872
Authors: Julie R Palmer; Emma Viscidi; Melissa A Troester; Chi-Chen Hong; Pepper Schedin; Traci N Bethea; Elisa V Bandera; Virginia Borges; Craig McKinnon; Christopher A Haiman; Kathryn Lunetta; Laurence N Kolonel; Lynn Rosenberg; Andrew F Olshan; Christine B Ambrosone Journal: J Natl Cancer Inst Date: 2014-09-15 Impact factor: 13.506
Authors: Danja Sarink; Kami K White; Lenora W M Loo; Anna H Wu; Lynne R Wilkens; Loïc Le Marchand; Song-Yi Park; V Wendy Setiawan; Melissa A Merritt Journal: Int J Cancer Date: 2021-09-16 Impact factor: 7.396