Jihong Wang1, Dianming Jiang1, Shuzheng Wen2, Shangfei Jing2, Dongsheng Fan2, Zengtao Hao2, Chaoqian Han2. 1. Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China. 2. Department of Hand and Microsurgery, The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot 010030, China.
Abstract
OBJECTIVE: To investigate the structure and the attachment strength of a healing tendon-bone interface and the role of mechanical loading in tendon healing. METHODS: Sixty rabbits underwent unilateral detachment and repair of the Achilles tendon. Thirty animals were immobilized (Group A), and the others wereallowed loadingimmediately postoperatively (Group B). Animals were sacrificed at 4 weeks and evaluated for histological and biomechanical testing. Statistical analysis was performed with an independent t test with significance set at P = 0.05. RESULTS: The ultimate stress was greater in group B (4.598 ± 1.321 N/mm(2)) compared with the control group (3.388 ± 0.994 N/mm(2)) (P < 0.05). Similarly, a more organized tendon-to-bone interface with a larger area of chondrocytes was found in group B (P < 0.05). CONCLUSION: Mechanical loading improves the structure and the attachment strength of the healing tendon-to-bone interface.
OBJECTIVE: To investigate the structure and the attachment strength of a healing tendon-bone interface and the role of mechanical loading in tendon healing. METHODS: Sixty rabbits underwent unilateral detachment and repair of the Achilles tendon. Thirty animals were immobilized (Group A), and the others wereallowed loadingimmediately postoperatively (Group B). Animals were sacrificed at 4 weeks and evaluated for histological and biomechanical testing. Statistical analysis was performed with an independent t test with significance set at P = 0.05. RESULTS: The ultimate stress was greater in group B (4.598 ± 1.321 N/mm(2)) compared with the control group (3.388 ± 0.994 N/mm(2)) (P < 0.05). Similarly, a more organized tendon-to-bone interface with a larger area of chondrocytes was found in group B (P < 0.05). CONCLUSION: Mechanical loading improves the structure and the attachment strength of the healing tendon-to-bone interface.
Entities:
Keywords:
Achilles tendon healing; mechanical loading; rabbit model
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