Huiyong Wu1, Wei Zhao2, Shuguang Liu3, Jinsong Zheng4, Guanglei Ji5, Yinfa Xie1. 1. Department of Interventional Radiology, Shandong Cancer Hospital Jinan, Shandong, China. 2. Department of Radiation Oncology, Shandong Cancer Hospital Jinan, Shandong, China. 3. Department of Thoracic Surgery, Shandong Cancer Hospital Jinan, Shandong, China. 4. PET-CT Center, Shandong Cancer Hospital Jinan, Shandong, China. 5. B-ultrasound Room, Shandong Cancer Hospital Jinan, Shandong, China.
Abstract
OBJECTIVE: Pulmonary metastasis of hepatocellular carcinoma (HCC) could be defined as advanced HCC and systematic treatment is the main therapeutic modality. However, local therapy of intrahepatic tumor, which is significantly associated with the prognosis of HCC, remains important for advanced HCC. METHODS: Twenty-six HCC patients with pulmonary metastasis underwent intrahepatic transcatheter arterial chemoembolization (TACE). We investigated the progression of lung metastastic tumors, overall survival and risk factors related to survival of these patients. RESULTS: Of the 26 patients who underwent TACE for one to four times, 10 patients achieved complete remission (CR) of intrahepatic tumors and among these 10 patients, 4 patients successfully received hepatic artery-venous shunt embolization combined with TACE. The lung metastasis lesions also achieved CR and the survival time was significantly longer than the other 22 patients. The lung metastastic lesions of the other 6 patients of intrahepatic tumors achieved stable disease (SD). Six patients acquired partial remission (PR) of intrahepatic tumors after TACE, while the lung metastastic lesions showed SD or progress disease (PD). Patients who showed CR and PR of intrahepatic tumors had longer survival time than patients with SD and PD. Portal vein tumor thrombus and size of the lung metastastic lesions were significant prognostic factors in these advanced HCC patients. CONCLUSIONS: With respect to HCC patients with lung metastasis, TACE was an effective and important therapeutic tool to control pulmonary metastatic tumor growth, and prolong the survival of advanced HCC patients, especially patients with hepatic artery-venous shunt.
OBJECTIVE: Pulmonary metastasis of hepatocellular carcinoma (HCC) could be defined as advanced HCC and systematic treatment is the main therapeutic modality. However, local therapy of intrahepatic tumor, which is significantly associated with the prognosis of HCC, remains important for advanced HCC. METHODS: Twenty-six HCC patients with pulmonary metastasis underwent intrahepatic transcatheter arterial chemoembolization (TACE). We investigated the progression of lung metastastic tumors, overall survival and risk factors related to survival of these patients. RESULTS: Of the 26 patients who underwent TACE for one to four times, 10 patients achieved complete remission (CR) of intrahepatic tumors and among these 10 patients, 4 patients successfully received hepatic artery-venous shunt embolization combined with TACE. The lung metastasis lesions also achieved CR and the survival time was significantly longer than the other 22 patients. The lung metastastic lesions of the other 6 patients of intrahepatic tumors achieved stable disease (SD). Six patients acquired partial remission (PR) of intrahepatic tumors after TACE, while the lung metastastic lesions showed SD or progress disease (PD). Patients who showed CR and PR of intrahepatic tumors had longer survival time than patients with SD and PD. Portal vein tumor thrombus and size of the lung metastastic lesions were significant prognostic factors in these advanced HCC patients. CONCLUSIONS: With respect to HCC patients with lung metastasis, TACE was an effective and important therapeutic tool to control pulmonary metastatic tumor growth, and prolong the survival of advanced HCC patients, especially patients with hepatic artery-venous shunt.
Authors: Kelvin K Ng; Chi Ming Lam; Ronnie T Poon; Tony W Shek; Jensen Y To; Yim Hung Wo; David W Ho; Sheung Tat Fan Journal: Ann Surg Oncol Date: 2004-07 Impact factor: 5.344
Authors: K Ohba; K Omagari; T Nakamura; N Ikuno; S Saeki; I Matsuo; H Kinoshita; J Masuda; H Hazama; I Sakamoto; S Kohno Journal: Gut Date: 1998-10 Impact factor: 23.059
Authors: Chang Young Lee; Mi Kyung Bae; In Kyu Park; Dae Joon Kim; Jin Gu Lee; Jin Sub Choi; Kwang-Hyub Han; Kyung Young Chung Journal: J Surg Oncol Date: 2010-03-01 Impact factor: 3.454