Zhengliang Li1, Qingfeng Zhu2, Zuojun Geng2, Zhenhu Song2, Lixin Wang2, Ya Wang2. 1. Department of Radiology, Second Hospital of Hebei Medical University Shijiazhuang, China ; Department of Radiology, Hebei Armed Police Hospital Shijiazhuang, China. 2. Department of Radiology, Second Hospital of Hebei Medical University Shijiazhuang, China.
Abstract
OBJECTIVE: To determine functional connectivity of the default mode network in patients with sensorineural hearing loss (SNHL) in resting state. METHODS: The posterior cingulate cortex was selected as a seed for assessment of functional connectivity of the activated brain areas in resting state by using a seed-based correlation analysis of the resting state functional magnetic resonance imaging (fMRI) data. RESULTS: The fMRI results demonstrated that, the healthy volunteers and the patients with NSHL shared certain activated brain areas with positive functional connectivity with region of interest (ROI). However, the healthy volunteers also had positive functional connectivity with ROI in bilateral middle temporal gyrus, left anterior cingulate cortex, right inferior parietal lobule and left medial superior frontal gyrus. While the patients with SNHL did with bilateral inferior parietal lobule, left medial superior frontal gyrus, right supramarginal gyrus, and left middle temporal gyrus. Compared to controls, patients with SNHL showed increased functional connectivity in the right posterior frontal lobe, right precentral gyrus, right supramarginal gyrus and left posterior cingulate cortex, and had decreased functional connectivity in the left lingual gyrus, right cuneus lobe and right superior frontal gyrus. CONCLUSION: The posterior cingulate cortex, precuneus lobe, medial frontal gyrus, anterior cingulate cortex, temporal lobe, angular gyrus and inferior parietal lobule constitute a default mode of network in normal resting status. And patients with SNHL have abnormal functional connectivity of default mode network and cortical reorganisation in resting status.
OBJECTIVE: To determine functional connectivity of the default mode network in patients with sensorineural hearing loss (SNHL) in resting state. METHODS: The posterior cingulate cortex was selected as a seed for assessment of functional connectivity of the activated brain areas in resting state by using a seed-based correlation analysis of the resting state functional magnetic resonance imaging (fMRI) data. RESULTS: The fMRI results demonstrated that, the healthy volunteers and the patients with NSHL shared certain activated brain areas with positive functional connectivity with region of interest (ROI). However, the healthy volunteers also had positive functional connectivity with ROI in bilateral middle temporal gyrus, left anterior cingulate cortex, right inferior parietal lobule and left medial superior frontal gyrus. While the patients with SNHL did with bilateral inferior parietal lobule, left medial superior frontal gyrus, right supramarginal gyrus, and left middle temporal gyrus. Compared to controls, patients with SNHL showed increased functional connectivity in the right posterior frontal lobe, right precentral gyrus, right supramarginal gyrus and left posterior cingulate cortex, and had decreased functional connectivity in the left lingual gyrus, right cuneus lobe and right superior frontal gyrus. CONCLUSION: The posterior cingulate cortex, precuneus lobe, medial frontal gyrus, anterior cingulate cortex, temporal lobe, angular gyrus and inferior parietal lobule constitute a default mode of network in normal resting status. And patients with SNHL have abnormal functional connectivity of default mode network and cortical reorganisation in resting status.
Entities:
Keywords:
Resting-status; functional connectivity; functional magnetic resonance imaging; sensorineural hearing loss
Authors: T Ohnishi; H Matsuda; T Asada; M Aruga; M Hirakata; M Nishikawa; A Katoh; E Imabayashi Journal: Cereb Cortex Date: 2001-08 Impact factor: 5.357
Authors: Kathleen Tibbetts; Banan Ead; Amy Umansky; Rebecca Coalson; Bradley L Schlaggar; Jill B Firszt; Judith E C Lieu Journal: Otolaryngol Head Neck Surg Date: 2011-02-14 Impact factor: 3.497
Authors: Shuihua Wang; Ming Yang; Sidan Du; Jiquan Yang; Bin Liu; Juan M Gorriz; Javier Ramírez; Ti-Fei Yuan; Yudong Zhang Journal: Front Comput Neurosci Date: 2016-10-19 Impact factor: 2.380
Authors: Tomasz Wolak; Katarzyna Cieśla; Agnieszka Pluta; Elżbieta Włodarczyk; Bharat Biswal; Henryk Skarżyński Journal: Front Hum Neurosci Date: 2019-08-22 Impact factor: 3.169