Literature DB >> 25781649

Potential treatments for genetic hearing loss in humans: current conundrums.

R Minoda1, T Miwa1, M Ise1, H Takeda1.   

Abstract

Genetic defects are a major cause of hearing loss in newborns. Consequently, hearing loss has a profound negative impact on human daily living. Numerous causative genes for genetic hearing loss have been identified. However, presently, there are no truly curative treatments for this condition. There have been several recent reports on successful treatments in mice using embryonic gene therapy, neonatal gene therapy and neonatal antisense oligonucleotide therapy. Herein, we describe state-of-the-art research on genetic hearing loss treatment through gene therapy and discuss the obstacles to overcome in curative treatments of genetic hearing loss in humans.

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Year:  2015        PMID： 25781649     DOI： 10.1038/gt.2015.27

Source DB:  PubMed          Journal:  Gene Ther        ISSN： 0969-7128            Impact factor:   5.250


  46 in total

Review 1.  Non-invasive prenatal testing using massively parallel sequencing of maternal plasma DNA: from molecular karyotyping to fetal whole-genome sequencing.

Authors:  Y M Dennis Lo
Journal:  Reprod Biomed Online       Date:  2013-09-07       Impact factor: 3.828

2.  A deletion involving the connexin 30 gene in nonsyndromic hearing impairment.

Authors:  Ignacio del Castillo; Manuela Villamar; Miguel A Moreno-Pelayo; Francisco J del Castillo; Araceli Alvarez; Dolores Tellería; Ibis Menéndez; Felipe Moreno
Journal:  N Engl J Med       Date:  2002-01-24       Impact factor: 91.245

Review 3.  SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct.

Authors:  Taku Ito; Byung Yoon Choi; Kelly A King; Christopher K Zalewski; Julie Muskett; Parna Chattaraj; Thomas Shawker; James C Reynolds; John A Butman; Carmen C Brewer; Philine Wangemann; Seth L Alper; Andrew J Griffith
Journal:  Cell Physiol Biochem       Date:  2011-11-18

4.  The Pendred syndrome gene encodes a chloride-iodide transport protein.

Authors:  D A Scott; R Wang; T M Kreman; V C Sheffield; L P Karniski
Journal:  Nat Genet       Date:  1999-04       Impact factor: 38.330

5.  Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential.

Authors:  Barbara Teubner; Vincent Michel; Jörg Pesch; Jürgen Lautermann; Martine Cohen-Salmon; Goran Söhl; Klaus Jahnke; Elke Winterhager; Claus Herberhold; Jean-Pierre Hardelin; Christine Petit; Klaus Willecke
Journal:  Hum Mol Genet       Date:  2003-01-01       Impact factor: 6.150

Review 6.  Mitochondrial ribosomal proteins: candidate genes for mitochondrial disease.

Authors:  James E Sylvester; Nathan Fischel-Ghodsian; Edward B Mougey; Thomas W O'Brien
Journal:  Genet Med       Date:  2004 Mar-Apr       Impact factor: 8.822

7.  A novel missense mutation in the connexin30 causes nonsyndromic hearing loss.

Authors:  Wen-Hung Wang; Yu-Fan Liu; Ching-Chyuan Su; Mao-Chang Su; Shuan-Yow Li; Jiann-Jou Yang
Journal:  PLoS One       Date:  2011-06-24       Impact factor: 3.240

8.  SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.

Authors:  Xiangming Li; Joel D Sanneman; Donald G Harbidge; Fei Zhou; Taku Ito; Raoul Nelson; Nicolas Picard; Régine Chambrey; Dominique Eladari; Tracy Miesner; Andrew J Griffith; Daniel C Marcus; Philine Wangemann
Journal:  PLoS Genet       Date:  2013-07-11       Impact factor: 5.917

9.  Virally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice.

Authors:  Q Yu; Y Wang; Q Chang; J Wang; S Gong; H Li; X Lin
Journal:  Gene Ther       Date:  2013-11-14       Impact factor: 5.250

Review 10.  GJB2 (connexin 26) variants and nonsyndromic sensorineural hearing loss: a HuGE review.

Authors:  Aileen Kenneson; Kim Van Naarden Braun; Coleen Boyle
Journal:  Genet Med       Date:  2002 Jul-Aug       Impact factor: 8.822
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  8 in total

Review 1.  Emerging Gene Therapies for Genetic Hearing Loss.

Authors:  Hena Ahmed; Olga Shubina-Oleinik; Jeffrey R Holt
Journal:  J Assoc Res Otolaryngol       Date:  2017-08-16

2.  Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss.

Authors:  Min-A Kim; Hyun-Ju Cho; Seung-Hyun Bae; Byeonghyeon Lee; Se-Kyung Oh; Tae-Jun Kwon; Zae-Young Ryoo; Hwa-Young Kim; Jin-Ho Cho; Un-Kyung Kim; Kyu-Yup Lee
Journal:  Antioxid Redox Signal       Date:  2016-01-21       Impact factor: 8.401

3.  Genetic hearing loss: the journey of discovery to destination - how close are we to therapy?

Authors:  Arti Pandya
Journal:  Mol Genet Genomic Med       Date:  2016-11-21       Impact factor: 2.183

4.  Role of Dach1 revealed using a novel inner ear-specific Dach1-knockdown mouse model.

Authors:  Toru Miwa; Ryosei Minoda; Yoshihide Ishikawa; Tomohito Kajii; Yorihisa Orita; Takahiro Ohyama
Journal:  Biol Open       Date:  2019-08-20       Impact factor: 2.422

5.  Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss.

Authors:  Chong Cui; Daqi Wang; Bowei Huang; Fang Wang; Yuxin Chen; Jun Lv; Luping Zhang; Lei Han; Dong Liu; Zheng-Yi Chen; Geng-Lin Li; Huawei Li; Yilai Shu
Journal:  Mol Ther Nucleic Acids       Date:  2022-07-20       Impact factor: 10.183

6.  Engraftment of Human Pluripotent Stem Cell-derived Progenitors in the Inner Ear of Prenatal Mice.

Authors:  Hiroki Takeda; Makoto Hosoya; Masato Fujioka; Chika Saegusa; Tsubasa Saeki; Toru Miwa; Hideyuki Okano; Ryosei Minoda
Journal:  Sci Rep       Date:  2018-01-31       Impact factor: 4.379

7.  Gene editing in a Myo6 semi-dominant mouse model rescues auditory function.

Authors:  Yuanyuan Xue; Xinde Hu; Daqi Wang; Di Li; Yige Li; Fang Wang; Mingqian Huang; Xi Gu; Zhijiao Xu; Jinan Zhou; Jinghan Wang; Renjie Chai; Jun Shen; Zheng-Yi Chen; Geng-Lin Li; Hui Yang; Huawei Li; Erwei Zuo; Yilai Shu
Journal:  Mol Ther       Date:  2021-06-24       Impact factor: 11.454

8.  Dynamic Spatiotemporal Expression Changes in Connexins of the Developing Primate's Cochlea.

Authors:  Makoto Hosoya; Masato Fujioka; Ayako Y Murayama; Kaoru Ogawa; Hideyuki Okano; Hiroyuki Ozawa
Journal:  Genes (Basel)       Date:  2021-07-16       Impact factor: 4.096
  8 in total

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