AIM: To evaluate clinical response to initial corticosteroid (CS) treatment in Chinese ulcerative colitis patients (UC) and identify predictors of clinical response. METHODS: Four hundred and twenty-three UC patients who were initially treated with oral or intravenous CS from 2007 to 2011 were retrospectively reviewed at eight inflammatory bowel disease centers in China, and 101 consecutive cases with one-year follow-up were analyzed further for clinical response and predictors. Short-term outcomes within one month were classified as primary response and primary non-response. Long-term outcomes within one year were classified as prolonged CS response, CS dependence and secondary non-response. CS refractoriness included primary and secondary non-response. Multivariate analyses were performed to identify predictors associated with clinical response. RESULTS: Within one month, 95.0% and 5.0% of the cases were classified into primary response and non-response, respectively. Within one year, 41.6% of cases were assessed as prolonged CS response, while 49.5% as CS dependence and 4.0% as secondary non-response. The rate of CS refractoriness was 8.9%, while the cumulative rate of surgery was 6.9% within one year. After multivariate analysis of all the variables, tenesmus was found to be a negative predictor of CS dependence (OR = 0.336; 95%CI: 0.147-0.768; P = 0.013) and weight loss as a predictor of CS refractoriness (OR = 5.662; 95%CI: 1.111-28.857; P = 0.040). After one-month treatment, sustained high Sutherland score (≥ 6) also predicted CS dependence (OR = 2.347; 95%CI: 0.935-5.890; P = 0.014). CONCLUSION: Tenesmus was a negative predictor of CS dependence, while weight loss and sustained high Sutherland score were strongly associated with poor CS response.
AIM: To evaluate clinical response to initial corticosteroid (CS) treatment in Chinese ulcerative colitispatients (UC) and identify predictors of clinical response. METHODS: Four hundred and twenty-three UC patients who were initially treated with oral or intravenous CS from 2007 to 2011 were retrospectively reviewed at eight inflammatory bowel disease centers in China, and 101 consecutive cases with one-year follow-up were analyzed further for clinical response and predictors. Short-term outcomes within one month were classified as primary response and primary non-response. Long-term outcomes within one year were classified as prolonged CS response, CS dependence and secondary non-response. CS refractoriness included primary and secondary non-response. Multivariate analyses were performed to identify predictors associated with clinical response. RESULTS: Within one month, 95.0% and 5.0% of the cases were classified into primary response and non-response, respectively. Within one year, 41.6% of cases were assessed as prolonged CS response, while 49.5% as CS dependence and 4.0% as secondary non-response. The rate of CS refractoriness was 8.9%, while the cumulative rate of surgery was 6.9% within one year. After multivariate analysis of all the variables, tenesmus was found to be a negative predictor of CS dependence (OR = 0.336; 95%CI: 0.147-0.768; P = 0.013) and weight loss as a predictor of CS refractoriness (OR = 5.662; 95%CI: 1.111-28.857; P = 0.040). After one-month treatment, sustained high Sutherland score (≥ 6) also predicted CS dependence (OR = 2.347; 95%CI: 0.935-5.890; P = 0.014). CONCLUSION: Tenesmus was a negative predictor of CS dependence, while weight loss and sustained high Sutherland score were strongly associated with poor CS response.
Authors: Jeanne Tung; Edward V Loftus; Deborah K Freese; Mounif El-Youssef; Alan R Zinsmeister; L Joseph Melton; W Scott Harmsen; William J Sandborn; William A Faubion Journal: Inflamm Bowel Dis Date: 2006-12 Impact factor: 5.325
Authors: D K L Chow; J J Y Sung; K K F Tsoi; V W S Wong; J C Y Wu; R W L Leong; F K L Chan Journal: Aliment Pharmacol Ther Date: 2009-01-20 Impact factor: 8.171
Authors: David R Mack; Christine Langton; James Markowitz; Neal LeLeiko; Anne Griffiths; Athos Bousvaros; Jonathan Evans; Subra Kugathasan; Anthony Otley; Mariann Pfefferkorn; Joel Rosh; Adam Mezoff; Susan Moyer; Maria Oliva-Hemker; Robert Rothbaum; Robert Wyllie; J Fernando delRosario; David Keljo; Trudy Lerer; Jeffrey Hyams Journal: Pediatrics Date: 2007-06 Impact factor: 7.124
Authors: Mona A Mohammed; Bassant M M Ibrahim; Yasmin Abdel-Latif; Azza H Hassan; Mohamed A El Raey; Emad M Hassan; Souad E El-Gengaihi Journal: Sci Rep Date: 2022-06-22 Impact factor: 4.996