Literature DB >> 25779946

PLEKHA5: A Key to Unlock the Blood-Brain Barrier?

Sylvia C Eisele1, Corey M Gill1, Ganesh M Shankar2, Priscilla K Brastianos3.   

Abstract

Brain metastases represent a devastating complication of melanoma. Our understanding of the mechanisms driving metastasis to the brain is limited. PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 25779946     DOI： 10.1158/1078-0432.CCR-14-2604

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  8 in total

1.  Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities?

Authors:  Gautham Gampa; Shruthi Vaidhyanathan; Jann N Sarkaria; William F Elmquist
Journal:  Pharmacol Res       Date:  2017-06-17       Impact factor: 7.658

2.  Challenges in the delivery of therapies to melanoma brain metastases.

Authors:  Gautham Gampa; Shruthi Vaidhyanathan; Brynna-Wilken Resman; Karen E Parrish; Svetomir N Markovic; Jann N Sarkaria; William F Elmquist
Journal:  Curr Pharmacol Rep       Date:  2016-11-09

3.  Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.

Authors:  Guy J Leclerc; Joanna DeSalvo; Jianfeng Du; Ningguo Gao; Gilles M Leclerc; Mark A Lehrman; Theodore J Lampidis; Julio C Barredo
Journal:  Leuk Res       Date:  2015-08-20       Impact factor: 3.156

4.  Genome-wide profiling of the PIWI-interacting RNA-mRNA regulatory networks in epithelial ovarian cancers.

Authors:  Garima Singh; Jyoti Roy; Pratiti Rout; Bibekanand Mallick
Journal:  PLoS One       Date:  2018-01-10       Impact factor: 3.240

Review 5.  Deciphering mechanisms of brain metastasis in melanoma - the gist of the matter.

Authors:  Torben Redmer
Journal:  Mol Cancer       Date:  2018-07-27       Impact factor: 27.401

6.  PLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification.

Authors:  Yuko Nagamura; Makoto Miyazaki; Yoshiko Nagano; Masako Yuki; Kiyoko Fukami; Kazuyoshi Yanagihara; Kazuki Sasaki; Ryuichi Sakai; Hideki Yamaguchi
Journal:  Oncogenesis       Date:  2021-03-06       Impact factor: 7.485

7.  Epigenetics Is Implicated in the Basis of Gender Incongruence: An Epigenome-Wide Association Analysis.

Authors:  Karla Ramirez; Rosa Fernández; Sarah Collet; Meltem Kiyar; Enrique Delgado-Zayas; Esther Gómez-Gil; Tibbert Van Den Eynde; Guy T'Sjoen; Antonio Guillamon; Sven C Mueller; Eduardo Pásaro
Journal:  Front Neurosci       Date:  2021-08-19       Impact factor: 4.677

8.  Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues.

Authors:  Dan Zhou; Bonnie M Alver; Shuang Li; Ryan A Hlady; Joyce J Thompson; Mark A Schroeder; Jeong-Heon Lee; Jingxin Qiu; Philip H Schwartz; Jann N Sarkaria; Keith D Robertson
Journal:  Genome Biol       Date:  2018-03-27       Impact factor: 13.583
  8 in total

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