James E Mitchell1, Wendy C King2, Walter Pories3, Bruce Wolfe4, David R Flum5, Konstatinos Spaniolas3, Mark Bessler6, Michael Devlin6, Marsha D Marcus7, Melissa Kalarchian8, Scott Engel1, Saurobh Khandelwal5, Susan Yanovski9. 1. Neuropsychiatric Research Institute, Fargo, North Dakota. 2. Data Coordinating Center, Graduate School of Public Health at the University of Pittsburgh, Pittsburgh, Pennsylvania. 3. Department of Surgery, East Carolina Medical Center, Greenville, North Carolina. 4. Department of Surgery, Oregon Health and Science University, Portland, Oregon. 5. Department of Surgery, University of Washington, Seattle, Washington. 6. Department of Psychiatry, Columbia University Medical Center, New York City, New York. 7. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. 8. College of Nursing, Dusquesne University, Pittsburgh, Pennsylvania. 9. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Abstract
OBJECTIVE: To determine whether binge eating disorder (BED) status is associated with medical comorbidities in obese adults scheduled for bariatric surgery. METHOD: The study utilized Longitudinal Assessment of Bariatric Surgery-2 data obtained from six clinical centers around the United States. This is a well-phenotyped cohort of individuals who were evaluated within 30 days before their scheduled surgery using standardized protocols. In the cohort, 350 participants were classified as having BED and 1,875 as not having BED (non-BED). Multivariable logistic regression was used to determine whether BED status was independently related to medical comorbidities. As an exploratory analysis, significance was based on nominal p-values (p < .05). Holm's-adjusted p-values were also reported. RESULTS: After adjusting for age, sex, education, and body mass index, BED status was found to be independently associated with four of the 15 comorbidities (i.e., impaired glucose levels (odds ratio [OR] = 1.45 (95% confidence interval [CI]: 1.12-1.87)), high triglycerides (OR = 1.28 (95% CI: 1.002-1.63)), and urinary incontinence (OR = 1.30 (95% CI: 1.02-1.66)), all being more common among the BED sample, and severe walking limitations being less common in the BED sample (OR = 0.53 (95% CI: 0.29-0.96)). With further adjustment for psychiatric/emotional health indicators, BED status was independently associated with three comorbidities (impaired glucose levels (OR = 1.36 (95% CI: 1.04-1.79)), cardiovascular disease (OR = 0.50 (95% CI: 0.30-0.86)), and severe walking limitations (OR = 0.38 (95% CI: 0.19-0.77)). However, Holm's-adjusted p-values for all variables were greater than .05. DISCUSSION: The results suggest the possibility of a contribution of BED to risk of specific medical comorbidities in severely obese adults.
OBJECTIVE: To determine whether binge eating disorder (BED) status is associated with medical comorbidities in obese adults scheduled for bariatric surgery. METHOD: The study utilized Longitudinal Assessment of Bariatric Surgery-2 data obtained from six clinical centers around the United States. This is a well-phenotyped cohort of individuals who were evaluated within 30 days before their scheduled surgery using standardized protocols. In the cohort, 350 participants were classified as having BED and 1,875 as not having BED (non-BED). Multivariable logistic regression was used to determine whether BED status was independently related to medical comorbidities. As an exploratory analysis, significance was based on nominal p-values (p < .05). Holm's-adjusted p-values were also reported. RESULTS: After adjusting for age, sex, education, and body mass index, BED status was found to be independently associated with four of the 15 comorbidities (i.e., impaired glucose levels (odds ratio [OR] = 1.45 (95% confidence interval [CI]: 1.12-1.87)), high triglycerides (OR = 1.28 (95% CI: 1.002-1.63)), and urinary incontinence (OR = 1.30 (95% CI: 1.02-1.66)), all being more common among the BED sample, and severe walking limitations being less common in the BED sample (OR = 0.53 (95% CI: 0.29-0.96)). With further adjustment for psychiatric/emotional health indicators, BED status was independently associated with three comorbidities (impaired glucose levels (OR = 1.36 (95% CI: 1.04-1.79)), cardiovascular disease (OR = 0.50 (95% CI: 0.30-0.86)), and severe walking limitations (OR = 0.38 (95% CI: 0.19-0.77)). However, Holm's-adjusted p-values for all variables were greater than .05. DISCUSSION: The results suggest the possibility of a contribution of BED to risk of specific medical comorbidities in severely obese adults.
Authors: James E Mitchell; Wendy C King; Anita Courcoulas; George Dakin; Katherine Elder; Scott Engel; David Flum; Melissa Kalarchian; Saurabh Khandelwal; John Pender; Walter Pories; Bruce Wolfe Journal: Int J Eat Disord Date: 2014-04-09 Impact factor: 4.861
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