Michiko Yamada1, Reid D Landes2, Yasuyo Mimori3, Yoshito Nagano4, Hideo Sasaki5. 1. Departments of Clinical Studies and Statistics, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, 732-0815, Japan. Electronic address: yamada@rerf.or.jp. 2. Departments of Clinical Studies and Statistics, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, 732-0815, Japan. Electronic address: rdlandes@rerf.or.jp. 3. Department of Physical Therapy, Hiroshima International University, 555-36 Gakuendai, Kurose, Higashi, Hiroshima, 739-2695, Japan. Electronic address: y-mimori@hs.hirokoku-u.ac.jp. 4. Department of Clinical Neuroscience and Therapeutics, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-0037, Japan. Electronic address: yachtz@hiroshima-u.ac.jp. 5. Department of Nutritional Sciences, Yasuda Women's University, 6-13-1, Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan. Electronic address: sasaki-h@yasuda-u.ac.jp.
Abstract
OBJECTIVES: To investigate associations between age, sex, education, and birth cohort and global cognitive decline among a population that would most likely not progress to dementia. METHODS: A total of 1538 dementia-free subjects aged 60 to 80years in 1992 were followed up through 2011 without dementia occurrence. We assessed cognitive function using the Cognitive Ability Screening Instrument (CASI). Using stepwise-like model selection procedure, we built mixed-effects models for initial cognition and longitudinal cognition. RESULTS: Initial CASI scores for younger age and more years of formal education were higher than those for older and less education. Sex did not show a significant effect. In the longitudinal analysis, cognitive decline became more rapid with increasing age. Sex and education did not modify the degree of deterioration with age. CASI scores were higher for younger cohorts and men due to differences in education levels. CONCLUSION: Among dementia-free subjects, age is an important predictor of cognitive function level and cognitive decline. Education level affects cognitive function level, but did not affect cognitive decline. The results have implications not only for elucidation of the aging process, but also for reference in dementia screening.
OBJECTIVES: To investigate associations between age, sex, education, and birth cohort and global cognitive decline among a population that would most likely not progress to dementia. METHODS: A total of 1538 dementia-free subjects aged 60 to 80years in 1992 were followed up through 2011 without dementia occurrence. We assessed cognitive function using the Cognitive Ability Screening Instrument (CASI). Using stepwise-like model selection procedure, we built mixed-effects models for initial cognition and longitudinal cognition. RESULTS: Initial CASI scores for younger age and more years of formal education were higher than those for older and less education. Sex did not show a significant effect. In the longitudinal analysis, cognitive decline became more rapid with increasing age. Sex and education did not modify the degree of deterioration with age. CASI scores were higher for younger cohorts and men due to differences in education levels. CONCLUSION: Among dementia-free subjects, age is an important predictor of cognitive function level and cognitive decline. Education level affects cognitive function level, but did not affect cognitive decline. The results have implications not only for elucidation of the aging process, but also for reference in dementia screening.
Authors: Rónán O'Caoimh; Yang Gao; Anton Svendovski; Paul Gallagher; Joseph Eustace; D William Molloy Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Michiko Yamada; Reid D Landes; Ayumi Hida; Kayoko Ishihara; Kevin R Krull Journal: Int J Environ Res Public Health Date: 2019-02-01 Impact factor: 3.390
Authors: Caroline Dupré; David Hupin; Luc Goethals; François Béland; Frédéric Roche; Thomas Célarier; Isabelle Carrière; Nathalie Barth; Bienvenu Bongue Journal: Front Public Health Date: 2020-12-09