Hyoseung Shin1, Hyeong Ho Ryu2, Ohsang Kwon2, Byung-Soon Park3, Seong Jin Jo1. 1. Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, South Korea. 2. Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea. 3. Cellpark Clinic, Seoul, South Korea.
Abstract
BACKGROUND: Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of alopecia using ADSC-CM. OBJECTIVES: This study evaluates our clinical experience in the use of ADSC-CM for the treatment of FPHL. METHODS: A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC-CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed. RESULTS: The application of ADSC-CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm(2) (P < 0.001). Hair thickness increased from 57.5 μm to 64.0 μm (P < 0.001). None of the patients reported severe adverse reactions. CONCLUSIONS: The application of ADSC-CM is a potential treatment option for FPHL.
BACKGROUND: Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of alopecia using ADSC-CM. OBJECTIVES: This study evaluates our clinical experience in the use of ADSC-CM for the treatment of FPHL. METHODS: A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC-CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed. RESULTS: The application of ADSC-CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm(2) (P < 0.001). Hair thickness increased from 57.5 μm to 64.0 μm (P < 0.001). None of the patients reported severe adverse reactions. CONCLUSIONS: The application of ADSC-CM is a potential treatment option for FPHL.