PURPOSE: To evaluate the potential of zein as a sole excipient for controlled release formulations prepared by hot melt extrusion. METHODS: Physical mixtures of zein, water and crystalline paracetamol were hot melt extruded (HME) at 80°C and injection moulded (IM) into caplet forms. HME-IM Caplets were characterised using differential scanning calorimetry, ATR-FTIR spectroscopy, scanning electron microscopy and powder X-ray diffraction. Hydration and drug release kinetics of the caplets were investigated and fitted to a diffusion model. RESULTS: For the formulations with lower drug loadings, the drug was found to be in the non-crystalline state, while for the ones with higher drug loadings paracetamol is mostly crystalline. Release was found to be largely independent of drug loading but strongly dependent upon device dimensions, and predominately governed by a Fickian diffusion mechanism, while the hydration kinetics shows the features of Case II diffusion. CONCLUSIONS: In this study a prototype controlled release caplet formulation using zein as the sole excipient was successfully prepared using direct HME-IM processing. The results demonstrated the unique advantage of the hot melt extruded zein formulations on the tuneability of drug release rate by alternating the device dimensions.
PURPOSE: To evaluate the potential of zein as a sole excipient for controlled release formulations prepared by hot melt extrusion. METHODS: Physical mixtures of zein, water and crystalline paracetamol were hot melt extruded (HME) at 80°C and injection moulded (IM) into caplet forms. HME-IM Caplets were characterised using differential scanning calorimetry, ATR-FTIR spectroscopy, scanning electron microscopy and powder X-ray diffraction. Hydration and drug release kinetics of the caplets were investigated and fitted to a diffusion model. RESULTS: For the formulations with lower drug loadings, the drug was found to be in the non-crystalline state, while for the ones with higher drug loadings paracetamol is mostly crystalline. Release was found to be largely independent of drug loading but strongly dependent upon device dimensions, and predominately governed by a Fickian diffusion mechanism, while the hydration kinetics shows the features of Case II diffusion. CONCLUSIONS: In this study a prototype controlled release caplet formulation using zein as the sole excipient was successfully prepared using direct HME-IM processing. The results demonstrated the unique advantage of the hot melt extruded zein formulations on the tuneability of drug release rate by alternating the device dimensions.
Authors: Matthew L Peterson; Sherry L Morissette; Chris McNulty; Andrew Goldsweig; Paul Shaw; Martin LeQuesne; Julie Monagle; Nicolas Encina; Joseph Marchionna; Alasdair Johnson; Javier Gonzalez-Zugasti; Anthony V Lemmo; Stephen J Ellis; Michael J Cima; Orn Almarsson Journal: J Am Chem Soc Date: 2002-09-18 Impact factor: 15.419
Authors: Thomas Gillgren; Susan A Barker; Peter S Belton; Dominique M R Georget; Mats Stading Journal: Biomacromolecules Date: 2009-05-11 Impact factor: 6.988
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