| Literature DB >> 12224925 |
Matthew L Peterson1, Sherry L Morissette, Chris McNulty, Andrew Goldsweig, Paul Shaw, Martin LeQuesne, Julie Monagle, Nicolas Encina, Joseph Marchionna, Alasdair Johnson, Javier Gonzalez-Zugasti, Anthony V Lemmo, Stephen J Ellis, Michael J Cima, Orn Almarsson.
Abstract
Three crystal forms of acetaminophen were prepared and characterized using a newly developed high-throughput crystallization platform, CrystalMax. The platform consists of design software, robotic sample dispensing and handling, and high-throughput microanalytics and is capable of running thousands of crystallizations in parallel using several different methods to drive supersaturation and subsequent crystallization. Additionally, structural models of the elusive third form of acetaminophen will be discussed on the basis of powder X-ray diffraction data. One structure suggested has a bilayer motif, held together by O-H...O(H) hydrogen bonds, and helps explain the difficulty associated with preparing this form from solution.Entities:
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Year: 2002 PMID： 12224925 DOI： 10.1021/ja020751w
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419