BACKGROUND: The aims of this study were to investigate the utility of neutrophil-to-lymphocyte ratio (NLR) as a simple and readily available predictor for clinical disease activity in inflammatory bowel disease (IBD). METHODS: Sixty-six patients (22 CD, 44 UC) and 41 healthy controls were enrolled in the study. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels and complete blood count (CBC) were measured. The neutrophil and lymphocyte counts were recorded and NLR was calculated. The patients with active or inactive UC and CD were classified according to the severity of the disease. RESULT: The serum NLR values of active CD patients were significantly higher than those of inactive ones and controls (p = 0.000, p = 0.000, respectively). NLR values of active UC patients were significantly higher than those of inactive ones and controls (p = 0.000, p = 0.000, respectively. The optimum NLR cut-off point for active CD and UC was 3.2 and 3.1. CONCLUSION: This study demonstrates that NLR in subjects with IBD is strongly associated with active disease and correlated with clinical and laboratory indices (Tab. 5, Fig. 2, Ref. 31).
BACKGROUND: The aims of this study were to investigate the utility of neutrophil-to-lymphocyte ratio (NLR) as a simple and readily available predictor for clinical disease activity in inflammatory bowel disease (IBD). METHODS: Sixty-six patients (22 CD, 44 UC) and 41 healthy controls were enrolled in the study. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels and complete blood count (CBC) were measured. The neutrophil and lymphocyte counts were recorded and NLR was calculated. The patients with active or inactive UC and CD were classified according to the severity of the disease. RESULT: The serum NLR values of active CDpatients were significantly higher than those of inactive ones and controls (p = 0.000, p = 0.000, respectively). NLR values of active UC patients were significantly higher than those of inactive ones and controls (p = 0.000, p = 0.000, respectively. The optimum NLR cut-off point for active CD and UC was 3.2 and 3.1. CONCLUSION: This study demonstrates that NLR in subjects with IBD is strongly associated with active disease and correlated with clinical and laboratory indices (Tab. 5, Fig. 2, Ref. 31).
Entities:
Keywords:
disease severity; inflammatory bowel disease.; neutrophil-to-lymphocyte ratio; new predictor
Authors: Shilpa Grover; Michael Dougan; Kevin Tyan; Anita Giobbie-Hurder; Steven M Blum; Jeffrey Ishizuka; Taha Qazi; Rawad Elias; Kruti B Vora; Alex B Ruan; William Martin-Doyle; Michael Manos; Lauren Eastman; Meredith Davis; Maria Gargano; Rizwan Haq; Elizabeth I Buchbinder; Ryan J Sullivan; Patrick A Ott; F Stephen Hodi; Osama E Rahma Journal: Cancer Date: 2020-06-22 Impact factor: 6.860
Authors: Moh'd Al-Halawani; Christian Kyung; Fei Liang; Ian Kaplan; Jane Moon; Guerrier Clerger; Bruce Sabin; Andrea Barnes; Mohammad Al-Ajam Journal: J Clin Sleep Med Date: 2020-01-13 Impact factor: 4.062