Literature DB >> 25773660

TGF-β signal transduction pathways and osteoarthritis.

Guangju Zhai1, Jules Doré, Proton Rahman.   

Abstract

Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-β/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-β/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.

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Year:  2015        PMID： 25773660     DOI： 10.1007/s00296-015-3251-z

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  95 in total

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  25 in total

1.  The polymorphism of SMAD3 rs1065080 is associated with increased risk for knee osteoarthritis.

Authors:  Chao Lu; Jin Shu; Yan Han; Xiao Yu Ren; Ke Xu; Hua Fan; Ying Pu Chen; Kan Peng
Journal:  Mol Biol Rep       Date:  2019-06-10       Impact factor: 2.316

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Journal:  ACS Nano       Date:  2021-08-19       Impact factor: 18.027

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Authors:  Chao Ye; Jing Chen; Yi Qu; Hui Qi; Qingfu Wang; Zheng Yang; Aiming Wu; Fengxian Wang; Pengyang Li
Journal:  J Orthop Translat       Date:  2021-08-06       Impact factor: 4.889

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Authors:  Xin Lu; Xisheng Weng; Zheng Li; Bo Yang; Jun Qian; Yue Huang
Journal:  Inflammopharmacology       Date:  2022-04-19       Impact factor: 5.093

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Journal:  Cell       Date:  2020-03-26       Impact factor: 41.582

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Authors:  Erfan Aref-Eshghi; Ming Liu; Patricia E Harper; Jules Doré; Glynn Martin; Andrew Furey; Roger Green; Proton Rahman; Guangju Zhai
Journal:  Arthritis Res Ther       Date:  2015-09-23       Impact factor: 5.156

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Authors:  Qiangqiang Lian; Bojing Chi; Liu Zhang; Faming Tian
Journal:  Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi       Date:  2020-06-15

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Journal:  Osteoarthritis Cartilage       Date:  2015-10-20       Impact factor: 6.576

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Journal:  BMC Vet Res       Date:  2016-07-01       Impact factor: 2.741
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