| Literature DB >> 25773369 |
Veronika Olejnickova1, Marie Novakova, Ivo Provaznik.
Abstract
Isolated heart model is a relevant tool for cardiovascular system studies. It represents a highly reproducible model for studying broad spectrum of biochemical, physiological, morphological, and pharmaceutical parameters, including analysis of intrinsic heart mechanics, metabolism, and coronary vascular response. Results obtained in this model are under no influence of other organ systems, plasma concentration of hormones or ions and influence of autonomic nervous system. The review describes various isolated heart models, the modes of heart perfusion, and advantages and limitations of various experimental setups. It reports the improvements of perfusion setup according to Langendorff introduced by the authors.Mesh:
Year: 2015 PMID: 25773369 DOI: 10.1007/s11517-015-1270-2
Source DB: PubMed Journal: Med Biol Eng Comput ISSN: 0140-0118 Impact factor: 2.602