Effect of antidepressant drugs and different receptor antagonists on the grooming induced by the dopamine D-1 agonist SKF 38393.

The effect of four antidepressant drugs: imipramine (IMI), amitriptyline (AMI), citalopram (CIT) and mianserin (MIA), as well as various receptor antagonists: prazosin (alpha 1), yohimbine (alpha 2), ritanserin (5-HT2), atropine (Ach), chlorpyramine (H1) and SCH 23,390 (D-1) on grooming potentiated by the selective D-1 receptor agonist SKF 38,393, as well as on spontaneous grooming was studied. Antidepressant drugs inhibited in a dose-dependent manner the SKF-38,393-induced grooming, as well as spontaneous grooming in rats and mice. A similar, dose-dependent inhibitory effect was shown by all the compounds mentioned above, which block various receptors. The results indicate that the inhibitory effect of antidepressants on the SKF 38,393-induced grooming is not specific.