Literature DB >> 2569028

Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist.

J Maj1, Z Rogóz, G Skuza, H Sowińska.   

Abstract

The effects of single or repeated doses of antidepressant drugs (imipramine, amitriptyline, citalopram, mianserin) on rat locomotor hyperactivity induced by quinpirole, a dopamine D-2 receptor agonist, was investigated. Single doses of antidepressants do not change the effect of quinpirole, but enhance it when they are administered repeatedly. This enhancement is inhibited by (+/-)-sulpiride, a dopamine D-2 receptor antagonist. The results obtained indicate that the enhancement of dopaminergically-stimulated hyperactivity induced by repeated doses of antidepressants is mediated by dopamine D-2 receptors.

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Year:  1989        PMID： 2569028     DOI： 10.1007/BF01247108

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  32 in total

1.  Effect of antidepressant drugs and different receptor antagonists on the grooming induced by the dopamine D-1 agonist SKF 38393.

Authors:  G Skuza; Z Rogóz; J Zak
Journal:  Pol J Pharmacol Pharm       Date:  1989 Sep-Oct

2.  Evidence that dopamine mechanisms in the nucleus accumbens are selectively involved in the effect of desipramine in the forced swimming test.

Authors:  L Cervo; R Samanin
Journal:  Neuropharmacology       Date:  1987-10       Impact factor: 5.250

Review 3.  Brain dopamine receptors.

Authors:  P Seeman
Journal:  Pharmacol Rev       Date:  1980-09       Impact factor: 25.468

4.  Repeated treatment with imipramine decreased the number of [3H]piflutixol binding sites in the rat striatum.

Authors:  V Klimek; M Nielsen; J Maj
Journal:  Eur J Pharmacol       Date:  1985-02-12       Impact factor: 4.432

5.  The D-2 agonist quinpirole releases striatal dopamine in vivo.

Authors:  T Sharp; T Zetterström; A K Collin; U Ungerstedt
Journal:  Eur J Pharmacol       Date:  1987-10-06       Impact factor: 4.432

6.  The influence of oxaprotiline enantiomers given repeatedly on the behavioural effects of d-amphetamine and dopamine injected into the nucleus accumbens.

Authors:  J Maj; K Wedzony
Journal:  Eur J Pharmacol       Date:  1988-01-12       Impact factor: 4.432

7.  Pharmacology of a new phthalane (Lu 10-171), with specific 5-HT uptake inhibiting properties.

Authors:  A V Christensen; B Fjalland; V Pedersen; P Danneskiold-Samsoe; O Svendsen
Journal:  Eur J Pharmacol       Date:  1977-01-21       Impact factor: 4.432

8.  Quinpirole hydrochloride, a potential anti-parkinsonism drug.

Authors:  W Koller; G Herbster; D Anderson; R Wack; J Gordon
Journal:  Neuropharmacology       Date:  1987-08       Impact factor: 5.250

9.  Chronic treatment with antidepressants decreases the number of [3H]SCH 23390 binding sites in the rat striatum and limbic system.

Authors:  V Klimek; M Nielsen
Journal:  Eur J Pharmacol       Date:  1987-07-09       Impact factor: 4.432

10.  Decrease in hypothalamic epinephrine concentration and other neurochemical changes produced by quinpirole, a dopamine agonist, in rats.

Authors:  R W Fuller; S K Hemrick-Luecke
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575
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  3 in total

1.  Antidepressant effects of pramipexole, a novel dopamine receptor agonist.

Authors:  J Maj; Z Rogóz; G Skuza; K Kołodziejczyk
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

2.  Roxindole, a potential antidepressant. I. Effect on the dopamine system.

Authors:  J Maj; K Kolodziejczyk; Z Rogóz; G Skuza
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

3.  The effect of (+)- and (-)-oxaprotiline administered repeatedly on the dopamine system.

Authors:  J Maj; V Klimek; Z Rogóz; G Skuza; H Sowińska
Journal:  J Neural Transm Gen Sect       Date:  1991
  3 in total

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