Literature DB >> 25769890

Cycloartenol triterpenoid saponins from Cimicifuga simplex (Ranunculaceae) and their biological effects.

Lun Wu1, Zhi-Li Chen1, Yang Su2, Qiu-Hong Wang1, Hai-Xue Kuang3.   

Abstract

The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga genus. This type of triterpenoid glycoside possesses several important biological activities. More than 120 cycloartane triterpene glycosides have been isolated from Cimicifuga simplex Wormsk. The aim of this review article is to summarize all the major findings based on the available scientific literatures on C. simplex, with a focus on the identified 9,19-cyclolanostane triterpenoid glycosides. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.
Copyright © 2015 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Biological effects; Cimicifuga simplex; Cycloartenol triterpenoid saponins; Ranunculaceae

Mesh：

Substances：

Year:  2015        PMID： 25769890      PMCID： PMC7130100          DOI： 10.1016/S1875-5364(15)60011-5

Source DB:  PubMed          Journal:  Chin J Nat Med        ISSN： 1875-5364


  25 in total

Review 1.  Cimicifugae rhizoma: from origins, bioactive constituents to clinical outcomes.

Authors:  Jian-Xin Li; Zhi-Yong Yu
Journal:  Curr Med Chem       Date:  2006       Impact factor: 4.530

2.  Studies on the constituents of Cimicifuga species. XXVIII. Cycloart-7-enol glycosides from the underground parts of Cimicifuga simplex Wormsk.

Authors:  A Kusano; M Shibano; D Tsukamoto; G Kusano
Journal:  Chem Pharm Bull (Tokyo)       Date:  2001-04       Impact factor: 1.645

3.  [Pharmacological studies on the Chinese crude drug "Shŏma". II. Anti-inflammatory action of Cimicifuga rhizoma, Cimicifuga simplex Wormsk (author's transl)].

Authors:  M Shibata; N Sakurai; M Onoda
Journal:  Yakugaku Zasshi       Date:  1977-08       Impact factor: 0.302

4.  Accuracy of detection of trichomonas vaginalis organisms on a liquid-based papanicolaou smear.

Authors:  Eduardo Lara-Torre; Jay S Pinkerton
Journal:  Am J Obstet Gynecol       Date:  2003-02       Impact factor: 8.661

5.  Chemical constituents from Cimicifuga foetida.

Authors:  Pei Cao; Xu-Feng Pu; Shu-Lin Peng; Xiao-Rong Zhang; Li-Sheng Ding
Journal:  J Asian Nat Prod Res       Date:  2005-04       Impact factor: 1.569

6.  Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells.

Authors:  Katarina Hostanska; Thomas Nisslein; Johannes Freudenstein; Juergen Reichling; Reinhard Saller
Journal:  Biol Pharm Bull       Date:  2004-12       Impact factor: 2.233

7.  Immunosuppressive effects of new cyclolanostane triterpene diglycosides from the aerial part of Cimicifuga foetida.

Authors:  Rui-Le Pan; Di-Hua Chen; Jian-Yong Si; Xiao-Hong Zhao; Zhan Li; Li Cao
Journal:  Arch Pharm Res       Date:  2009-03-13       Impact factor: 4.946

8.  Estrogen-like effect of a Cimicifuga racemosa extract sub-fraction as assessed by in vivo, ex vivo and in vitro assays.

Authors:  P Bolle; S Mastrangelo; F Perrone; M G Evandri
Journal:  J Steroid Biochem Mol Biol       Date:  2007-06-22       Impact factor: 4.292

9.  Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex.

Authors:  Ayako Yawata; Yuko Matsuhashi; Hanako Kato; Keiko Uemura; Genjiro Kusano; Junko Ito; Toshiyuki Chikuma; Hiroshi Hojo
Journal:  Eur J Pharm Sci       Date:  2009-09-11       Impact factor: 4.384

10.  Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells.

Authors:  Li-Rong Sun; Chen Qing; Yan-Li Zhang; Shu-Yu Jia; Zhong-Rong Li; Shen-Ji Pei; Ming-Hua Qiu; Michael L Gross; Samuel X Qiu
Journal:  Beilstein J Org Chem       Date:  2007-01-31       Impact factor: 2.883
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  4 in total

1.  Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway.

Authors:  Shushu Qian; Xuan Han; Xiaocao Sha; Fang Tian; Hong Huang; Pengjun Jiang; Guoshun Huang; Bangyun Ma; Hong Zhang; Yiye Zhu; Xuemei Sun
Journal:  J Inflamm Res       Date:  2022-02-15

2.  Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.

Authors:  Yin Nian; Ni-Hong Lu; Xiao-Ling Liu; Da-Shan Li; Lin Zhou; Ming-Hua Qiu
Journal:  RSC Adv       Date:  2018-02-19       Impact factor: 4.036

3.  Immunomodulatory Effect of Agave tequilana Evaluated on an Autoimmunity Like-SLE Model Induced in Balb/c Mice with Pristane.

Authors:  Zúlima Jannette Gutiérrez Nava; Antonio Ruperto Jiménez-Aparicio; Maribel Lucila Herrera-Ruiz; Enrique Jiménez-Ferrer
Journal:  Molecules       Date:  2017-05-25       Impact factor: 4.411

4.  Fibrous Roots of Cimicifuga Are at Risk of Hepatotoxicity.

Authors:  Yang Yu; Jialiang Tan; Jianing Nie; Chongning Lv; Jincai Lu
Journal:  Molecules       Date:  2022-01-29       Impact factor: 4.411
  4 in total

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