Literature DB >> 2576652

Organization of human class I homeobox genes.

E Boncinelli1, D Acampora, M Pannese, M D'Esposito, R Somma, G Gaudino, A Stornaiuolo, M Cafiero, A Faiella, A Simeone.   

Abstract

We report the genomic organization of 20 human class I homeoboxes and the predicted primary sequence of the encoded homeodomains. These homeoboxes are clustered in four complex HOX loci on chromosomes 2, 7, 12, and 17. The homeoboxes of one HOX locus can be aligned to the homeoboxes of the other HOX loci so that corresponding homeodomains in all loci can share the maximal peptide sequence identity. This correspondence of individual homeoboxes in different chromosomal loci suggests the hypothesis of large-scale duplications of a single complex locus. The existence of an ancestral complex locus might have predated the divergence of vertebrates and invertebrates.

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Year:  1989        PMID： 2576652     DOI： 10.1139/g89-133

Source DB:  PubMed          Journal:  Genome        ISSN： 0831-2796            Impact factor:   2.166


  10 in total

1.  Molecular characterization of the zerknüllt region of the Antennapedia complex of D. subobscura.

Authors:  J Terol; M Perez-Alonso; R de Frutos
Journal:  Chromosoma       Date:  1995-05       Impact factor: 4.316

2.  Isolation and characterization of the human homeobox gene HOX D1.

Authors:  B Appukuttan; R Sood; S Ott; I Makalowska; R J Patel; X Wang; C M Robbins; M J Brownstein; J T Stout
Journal:  Mol Biol Rep       Date:  2000       Impact factor: 2.316

3.  Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.

Authors:  U Thorsteinsdottir; G Sauvageau; M R Hough; W Dragowska; P M Lansdorp; H J Lawrence; C Largman; R K Humphries
Journal:  Mol Cell Biol       Date:  1997-01       Impact factor: 4.272

4.  Homeobox genes are expressed in the retina and brain of adult goldfish.

Authors:  E M Levine; N Schechter
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

5.  Establishment of stable melanoma cell line expressing a novel gene, jpk, using a tetracycline-controlled gene expression system.

Authors:  Byung-Gyu Kim; Meang Sub Cheng; Hyoung Woo Park; Myoung Hee Kim
Journal:  Mol Biotechnol       Date:  2004-01       Impact factor: 2.695

6.  Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.

Authors:  A Kuliev; V Kukharenko; G Morozov; M Freidine; S Rechitsky; O Verlinsky; V Ivakhnenko; V Gindilis; C Strom; Y Verlinsky
Journal:  J Assist Reprod Genet       Date:  1996-02       Impact factor: 3.412

7.  Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

Authors:  A Simeone; M Gulisano; D Acampora; A Stornaiuolo; M Rambaldi; E Boncinelli
Journal:  EMBO J       Date:  1992-07       Impact factor: 11.598

8.  The expression of murine Hox-2 genes is dependent on the differentiation pathway and displays a collinear sensitivity to retinoic acid in F9 cells and Xenopus embryos.

Authors:  N Papalopulu; R Lovell-Badge; R Krumlauf
Journal:  Nucleic Acids Res       Date:  1991-10-25       Impact factor: 16.971

9.  MiR-139-5p inhibits the tumorigenesis and progression of oral squamous carcinoma cells by targeting HOXA9.

Authors:  Kai Wang; Jun Jin; Tengxiao Ma; Hongfeng Zhai
Journal:  J Cell Mol Med       Date:  2017-08-05       Impact factor: 5.310

10.  Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation.

Authors:  Boris Novakovic; Thierry Fournier; Lynda K Harris; Joanna James; Claire T Roberts; Hannah E J Yong; Bill Kalionis; Danièle Evain-Brion; Peter R Ebeling; Euan M Wallace; Richard Saffery; Padma Murthi
Journal:  Sci Rep       Date:  2017-07-03       Impact factor: 4.379
  10 in total

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