Timothy W Liwosz1, Sherry R Chemler1. 1. Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY, 14620, United States.
Abstract
A copper-catalyzed intramolecular alkene oxidative amination that utilizes TEMPO as co-catalyst and O2 as the terminal oxidant has been developed. The method furnishes N-aryl and N-sulfonyl indoles from N-aryl and N-sulfonyl 2-vinylanilines, respectively. Additionally, sequential copper-catalyzed reactions where initial Chan-Lam coupling of 2-vinylanilines with arylboronic acids is followed by oxidative amination of the alkene can generate N-aryl indoles in one pot.
A copper-catalyzed intramolen class="Chemical">cularalkene oxidative amination that utilizes TEMPO as co-catalyst and O2 as the terminal oxidant has been developed. The method furnishes N-aryl and N-sulfonyl indoles from N-aryl and N-sulfonyl 2-vinylanilines, respectively. Additionally, sequential copper-catalyzed reactions where initial Chan-Lam coupling of 2-vinylanilines with arylboronic acids is followed by oxidative amination of the alkene can generate N-aryl indoles in one pot.
Authors: Thomas Jensen; Henrik Pedersen; Benny Bang-Andersen; Robert Madsen; Morten Jørgensen Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336
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