Juan R Bustillo1,2, Nathan Rediske1, Thomas Jones1, Laura M Rowland3, Christopher Abbott1, S Andrea Wijtenburg3. 1. Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico, USA. 2. Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA. 3. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Abstract
PURPOSE: To determine the reproducibility and reliability of glutamine (Gln), measured with a very short echo time phase rotation stimulated echo acquisition mode (VTE-PR STEAM) sequence at 3T, in subjects with schizophrenia. METHODS: Seven subjects with schizophrenia were scanned twice with VTE-PR STEAM in a Siemens 3T TIM Trio scanner with a 32-channel head coil. Spectroscopic data were collected from two voxels in gray matter, one in the dorsal anterior cingulate and the other in the medial occipital cortex. Reproducibility was assessed using coefficients of variation (CVs) and reliability with standard error of measurement and intraclass correlations (ICCs). Phantoms containing increasing concentrations of Gln in a physiologic solution of other neurometabolites with overlapping resonances were scanned to assess the validity of spectral Gln measurement. RESULTS: Very good reliability and reproducibility for Gln in both regions of interest were supported by CVs of ≤10.0% and ICCs of ≥0.6, respectively. Phantom studies documented a robust correspondence between known Gln concentrations and VTE-PR STEAM measurements of this metabolite (R(2) = 0.988). CONCLUSION: The VTE-PR STEAM approach at 3T permits the longitudinal assessment of Gln and other (1) H MR spectroscopy neurometabolites in a clinically plausible setting.
PURPOSE: To determine the reproducibility and reliability of glutamine (Gln), measured with a very short echo time phase rotation stimulated echo acquisition mode (VTE-PR STEAM) sequence at 3T, in subjects with schizophrenia. METHODS: Seven subjects with schizophrenia were scanned twice with VTE-PR STEAM in a Siemens 3T TIM Trio scanner with a 32-channel head coil. Spectroscopic data were collected from two voxels in gray matter, one in the dorsal anterior cingulate and the other in the medial occipital cortex. Reproducibility was assessed using coefficients of variation (CVs) and reliability with standard error of measurement and intraclass correlations (ICCs). Phantoms containing increasing concentrations of Gln in a physiologic solution of other neurometabolites with overlapping resonances were scanned to assess the validity of spectral Gln measurement. RESULTS: Very good reliability and reproducibility for Gln in both regions of interest were supported by CVs of ≤10.0% and ICCs of ≥0.6, respectively. Phantom studies documented a robust correspondence between known Gln concentrations and VTE-PR STEAM measurements of this metabolite (R(2) = 0.988). CONCLUSION: The VTE-PR STEAM approach at 3T permits the longitudinal assessment of Gln and other (1) H MR spectroscopy neurometabolites in a clinically plausible setting.
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