Il Young Kim1,2, Min Jung Kim1,2, Dong Won Lee1,2, Soo Bong Lee3,4, Min Ji Shin1,5, Harin Rhee1,5, Byeong Yun Yang1,5, Sang Heon Song1,5, Eun Young Seong1,5, Ihm Soo Kwak1,5. 1. Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. 2. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea. 3. Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, 626-770, Gyeongsangnam-do, South Korea. sbleemd@pusan.ac.kr. 4. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea. sbleemd@pusan.ac.kr. 5. Medical Research Institute, Pusan National University Hospital, Busan, South Korea.
Abstract
BACKGROUND: Cardiac valve calcification is common in chronic kidney disease (CKD) patients. Coronary artery disease (CAD) is the one of major causes for increased cardiovascular mortality in CKD patients. We hypothesized that cardiac valve calcification is associated with the presence and the severity of CAD in pre-dialysis CKD patients. METHODS: This study included 1166 patients who underwent transthoracic echocardiography for assessment of cardiac valve calcification and coronary angiography for assessment of CAD. The patients were divided into two groups according to estimated glomerular filtration rate (eGFR): pre-dialysis CKD group (n = 215, eGFR < 60 ml/min/1.73 m(2)) and non-CKD group (n = 951, eGFR ≥ 60 ml/min/1.73 m(2)). RESULTS: In the pre-dialysis CKD group, subjects with aortic valve calcification (AVC), mitral valve calcification (MVC), and at least one valve calcification had more severe CAD compared with those without AVC, MVC, and any valve calcification. Multivariate analysis showed that pre-dialysis CKD patients who had AVC, MVC, and at least one valve calcification were 3.02 times (P = 0.033), 3.73 times (P = 0.029), and 3.31 times (P = 0.012) more likely to have CAD compared with those without AVC, MVC, and any valve calcification, respectively. However, in the non-CKD group, there was no association between cardiac valve calcification and the severity/presence of CAD. CONCLUSIONS: Cardiac valve calcification is associated with the presence and severity of CAD in pre-dialysis CKD. Assessment of cardiac valve calcification by means of transthoracic echocardiography could be a valuable non-invasive method for CAD risk stratification in pre-dialysis CKD patients.
BACKGROUND:Cardiac valve calcification is common in chronic kidney disease (CKD) patients. Coronary artery disease (CAD) is the one of major causes for increased cardiovascular mortality in CKDpatients. We hypothesized that cardiac valve calcification is associated with the presence and the severity of CAD in pre-dialysis CKDpatients. METHODS: This study included 1166 patients who underwent transthoracic echocardiography for assessment of cardiac valve calcification and coronary angiography for assessment of CAD. The patients were divided into two groups according to estimated glomerular filtration rate (eGFR): pre-dialysis CKD group (n = 215, eGFR < 60 ml/min/1.73 m(2)) and non-CKD group (n = 951, eGFR ≥ 60 ml/min/1.73 m(2)). RESULTS: In the pre-dialysis CKD group, subjects with aortic valve calcification (AVC), mitral valve calcification (MVC), and at least one valve calcification had more severe CAD compared with those without AVC, MVC, and any valve calcification. Multivariate analysis showed that pre-dialysis CKDpatients who had AVC, MVC, and at least one valve calcification were 3.02 times (P = 0.033), 3.73 times (P = 0.029), and 3.31 times (P = 0.012) more likely to have CAD compared with those without AVC, MVC, and any valve calcification, respectively. However, in the non-CKD group, there was no association between cardiac valve calcification and the severity/presence of CAD. CONCLUSIONS:Cardiac valve calcification is associated with the presence and severity of CAD in pre-dialysis CKD. Assessment of cardiac valve calcification by means of transthoracic echocardiography could be a valuable non-invasive method for CAD risk stratification in pre-dialysis CKDpatients.
Authors: Rajan Sharma; Denis Pellerin; David C Gaze; Rajnikant L Mehta; Helen Gregson; Christopher P Streather; Paul O Collinson; Stephen J D Brecker Journal: Atherosclerosis Date: 2006-05-02 Impact factor: 5.162
Authors: Paolo Raggi; Antonio Bellasi; Christopher Gamboa; Emiliana Ferramosca; Carlo Ratti; Geoffrey A Block; Paul Muntner Journal: Clin J Am Soc Nephrol Date: 2011-06-23 Impact factor: 8.237
Authors: Caroline S Fox; Martin G Larson; Ramachandran S Vasan; Chao-Yu Guo; Helen Parise; Daniel Levy; Eric P Leip; Christopher J O'donnell; Ralph B D'Agostino; Emelia J Benjamin Journal: J Am Soc Nephrol Date: 2005-12-28 Impact factor: 10.121
Authors: Ronald M A Henry; Piet J Kostense; Griët Bos; Jacqueline M Dekker; Giel Nijpels; Robert J Heine; Lex M Bouter; Coen D A Stehouwer Journal: Kidney Int Date: 2002-10 Impact factor: 10.612
Authors: Joachim H Ix; Michael G Shlipak; Ronit Katz; Matthew J Budoff; David M Shavelle; Jeffrey L Probstfield; Junichiro Takasu; Robert Detrano; Kevin D O'Brien Journal: Am J Kidney Dis Date: 2007-09 Impact factor: 8.860
Authors: Lu Dai; Oscar Plunde; Abdul Rashid Qureshi; Bengt Lindholm; Torkel B Brismar; Leon J Schurgers; Magnus Söderberg; Jonaz Ripsweden; Magnus Bäck; Peter Stenvinkel Journal: J Clin Med Date: 2020-02-24 Impact factor: 4.241
Authors: Lan Wang; Hong Cheng; Xinrong Zou; Jun Yuan; Wenjing Wu; Siping Han; Jinwei Wang; Luxia Zhang; Kevin He; Ming-Hui Zhao; Xiaoqin Wang Journal: Front Public Health Date: 2022-01-06
Authors: Il Young Kim; Byung Min Ye; Min Jeong Kim; Seo Rin Kim; Dong Won Lee; Hyo Jin Kim; Harin Rhee; Sang Heon Song; Eun Young Seong; Soo Bong Lee Journal: Sci Rep Date: 2022-01-18 Impact factor: 4.379