BACKGROUND: We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. METHODS: Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was defined as luminal stenosis >70% by visual estimation in at least one coronary artery. RESULTS: There were 21 deaths over a follow-up period of 2.2+/-0.7 years. MAC occurred in 56 patients (40%) and was associated with higher mortality (p=0.04). Patients with MAC were older (p=or<0.001), had larger left ventricular (LV) end systolic (p=0.005) and LV end diastolic (p=0.04) diameter, larger left atrial diameter (p=0.001), lower LV fractional shortening (p=0.003), larger LV mass index (p=0.04) and higher mitral E/Ea ratio (p=0.03) compared to those without. Plasma calcium (p=0.002), phosphate (p=0.004), cardiac troponin T (p=0.03), N-terminal Pro-B-type natriuretic peptide (p=0.004) concentrations were higher in those with MAC but gender, total cholesterol, haemoglobin and creatinine were similar in the two groups. The proportion diabetic (p=0.03), on dialysis (p=0.05), with significant CAD (p=or<0.001), taking calcium containing phosphate binders (p=0.02) and Vitamin D3 (p=0.04) was significantly higher in those with MAC. Significant CAD (OR 12, 95% CI 3.25, p=0.001) was the only independent associate of MAC. CONCLUSIONS: MAC is associated with increased mortality and significant CAD in ESRD. These patients have increased LV cavity size, poorer LV systolic function, higher LV filling pressures compared to patients without MAC.
BACKGROUND: We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. METHODS: Hundred and forty patients were prospectively studied. All had echocardiography and coronary angiography. Significant coronary artery disease (CAD) was defined as luminal stenosis >70% by visual estimation in at least one coronary artery. RESULTS: There were 21 deaths over a follow-up period of 2.2+/-0.7 years. MAC occurred in 56 patients (40%) and was associated with higher mortality (p=0.04). Patients with MAC were older (p=or<0.001), had larger left ventricular (LV) end systolic (p=0.005) and LV end diastolic (p=0.04) diameter, larger left atrial diameter (p=0.001), lower LV fractional shortening (p=0.003), larger LV mass index (p=0.04) and higher mitral E/Ea ratio (p=0.03) compared to those without. Plasma calcium (p=0.002), phosphate (p=0.004), cardiac troponin T (p=0.03), N-terminal Pro-B-type natriuretic peptide (p=0.004) concentrations were higher in those with MAC but gender, total cholesterol, haemoglobin and creatinine were similar in the two groups. The proportion diabetic (p=0.03), on dialysis (p=0.05), with significant CAD (p=or<0.001), taking calcium containing phosphate binders (p=0.02) and Vitamin D3 (p=0.04) was significantly higher in those with MAC. Significant CAD (OR 12, 95% CI 3.25, p=0.001) was the only independent associate of MAC. CONCLUSIONS: MAC is associated with increased mortality and significant CAD in ESRD. These patients have increased LV cavity size, poorer LV systolic function, higher LV filling pressures compared to patients without MAC.
Authors: Il Young Kim; Min Jung Kim; Dong Won Lee; Soo Bong Lee; Min Ji Shin; Harin Rhee; Byeong Yun Yang; Sang Heon Song; Eun Young Seong; Ihm Soo Kwak Journal: Clin Exp Nephrol Date: 2015-03-12 Impact factor: 2.801
Authors: Paolo Raggi; Antonio Bellasi; Christopher Gamboa; Emiliana Ferramosca; Carlo Ratti; Geoffrey A Block; Paul Muntner Journal: Clin J Am Soc Nephrol Date: 2011-06-23 Impact factor: 8.237
Authors: Jayson Rakesh Baman; Joseph Knapper; Zankhana Raval; Matthew E Harinstein; John J Friedewald; Kameswari Maganti; Michael J Cuttica; Michael I Abecassis; Ziad A Ali; Mihai Gheorghiade; James D Flaherty Journal: Clin J Am Soc Nephrol Date: 2019-09-25 Impact factor: 8.237
Authors: Luiz Rafael P Cavalcanti; Michel Pompeu B O Sá; Álvaro M Perazzo; Antonio C Escorel Neto; Rafael A F Gomes; Alexander Weymann; Konstantin Zhigalov; Arjang Ruhparwar; Ricardo C Lima Journal: Curr Atheroscler Rep Date: 2020-02-07 Impact factor: 5.113
Authors: Binita Shah; Pedro A Villablanca; Sreekanth Vemulapalli; Pratik Manandhar; Nicholas S Amoroso; Muhamed Saric; Cezar Staniloae; Mathew R Williams Journal: Circ Cardiovasc Interv Date: 2019-02 Impact factor: 6.546
Authors: Ilana Chefetz; Danny Ben Amitai; Sarah Browning; Karl Skorecki; Noam Adir; Mark G Thomas; Larissa Kogleck; Orit Topaz; Margarita Indelman; Jouni Uitto; Gabriele Richard; Neil Bradman; Eli Sprecher Journal: J Invest Dermatol Date: 2007-12-20 Impact factor: 8.551