Literature DB >> 25756142

Polyunsaturated fatty acids and fetal brain development.

Gideon Koren.   

Abstract

QUESTION: I have learned that one of the manufacturers of prenatal vitamins has added omega-3 fatty acids and claims that they help support fetal cognitive health and brain function. Is this based on evidence? ANSWER: The claim that polyunsaturated fatty acids help improve fetal brain and eye development has been made for more than a decade. Unfortunately it is not supported by evidence-based science. Long-term studies have failed to show such effects. Implying to women that using these products will improve the brain development of their children is unwarranted and misleading. Health Canada should clarify the contradictions in its statements about omega-3 fatty acids.

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Year:  2015        PMID： 25756142      PMCID： PMC4301762     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN： 0008-350X            Impact factor:   3.275


  11 in total

1.  Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trial.

Authors:  J A Dunstan; K Simmer; G Dixon; S L Prescott
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2006-12-21       Impact factor: 5.747

2.  Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation.

Authors:  Maria Makrides; Jacqueline F Gould; Nicola R Gawlik; Lisa N Yelland; Lisa G Smithers; Peter J Anderson; Robert A Gibson
Journal:  JAMA       Date:  2014-05-07       Impact factor: 56.272

Review 3.  Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials.

Authors:  Hania Szajewska; Andrea Horvath; Berthold Koletzko
Journal:  Am J Clin Nutr       Date:  2006-06       Impact factor: 7.045

4.  Omega-3 fatty acid supplementation during pregnancy: for mother, baby, or neither?

Authors:  Gal Dubnov-Raz; Yaron Finkelstein; Gideon Koren
Journal:  Can Fam Physician       Date:  2007-05       Impact factor: 3.275

5.  Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age.

Authors:  Ingrid B Helland; Lars Smith; Birgitta Blomén; Kristin Saarem; Ola D Saugstad; Christian A Drevon
Journal:  Pediatrics       Date:  2008-08       Impact factor: 7.124

Review 6.  Prenatal long-chain polyunsaturated fatty acid status: the importance of a balanced intake of docosahexaenoic acid and arachidonic acid.

Authors:  Mijna Hadders-Algra
Journal:  J Perinat Med       Date:  2008       Impact factor: 1.901

7.  Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo.

Authors:  Michelle P Judge; Ofer Harel; Carol J Lammi-Keefe
Journal:  Am J Clin Nutr       Date:  2007-06       Impact factor: 7.045

8.  The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations.

Authors:  Berthold Koletzko; Eric Lien; Carlo Agostoni; Hansjosef Böhles; Cristina Campoy; Irene Cetin; Tamas Decsi; Joachim W Dudenhausen; Cristophe Dupont; Stewart Forsyth; Irene Hoesli; Wolfgang Holzgreve; Alexandre Lapillonne; Guy Putet; Niels J Secher; Mike Symonds; Hania Szajewska; Peter Willatts; Ricardo Uauy
Journal:  J Perinat Med       Date:  2008       Impact factor: 1.901

9.  Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age.

Authors:  Ingrid B Helland; Lars Smith; Kristin Saarem; Ola D Saugstad; Christian A Drevon
Journal:  Pediatrics       Date:  2003-01       Impact factor: 7.124

10.  The effects of maternal supplementation of polyunsaturated Fatty acids on visual, neurobehavioural, and developmental outcomes of the child: a systematic review of the randomized trials.

Authors:  Andrea Lo; Julianna Sienna; Eva Mamak; Nada Djokanovic; Carol Westall; Gideon Koren
Journal:  Obstet Gynecol Int       Date:  2012-01-18
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  1 in total

Review 1.  Is there A Role for Alpha-Linolenic Acid in the Fetal Programming of Health?

Authors:  Alicia I Leikin-Frenkel
Journal:  J Clin Med       Date:  2016-03-23       Impact factor: 4.241
  1 in total

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